Study of membranotropic and antioxidant activity of flavonoids and their complexes with ferric iron

被引：2
|
作者：
Yagolnik E.A. [1 ]
Tarahovsky Y.S. [2 ]
Klenina I.B. [3 ]
Kuznetsova S.M. [2 ]
Muzafarov E.N. [1 ]
Kim Y.A. [4 ]
机构：
[1] Tula State University, Tula
[2] Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region
[3] Institute of Fundamental Problems of Biology, Russian Academy of Sciences, Pushchino, Moscow Region
[4] Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region
来源：
Biophysics | 2013年 / 58卷 / 5期
关键词：
antioxidant activity; catechin; complexes of flavonoids with ferric iron; liposomes; quercetin; taxifolin;
D O I：
10.1134/S0006350913050187
中图分类号：
学科分类号：
摘要：
We studied the interaction with liposomes and the antioxidant activity of flavonoid (quercetin, catechin, taxifolin) complexes with iron(III). It was found that the lipophilicity of complexes depends on an iron:flavonoid ratio and grows at a ratio of 1 to 1, while complexes in a 2: 1 ratio were the most effective to slow down the lipid peroxidation and restore radical 2,2-diphenyl-1-picrylhydrazyl. Thus, the stoichiometry of complexes formed in aqueous solution, may differ from the stoichiometry of complexes that most effectively protect membranes from peroxidation. © 2013 Pleiades Publishing, Inc.
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收藏
页码：646 / 652
页数：6
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