Randomized study of chemotherapy and surgery versus radiotherapy for stage IIIA non-small-cell lung cancer: a National Cancer Institute of Canada Clinical Trials Group Study
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作者:
FA Shepherd
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机构:Interdepartmental Division of Oncology of the University of Toronto,
FA Shepherd
MR Johnston
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机构:Interdepartmental Division of Oncology of the University of Toronto,
MR Johnston
D Payne
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机构:Interdepartmental Division of Oncology of the University of Toronto,
D Payne
R Burkes
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机构:Interdepartmental Division of Oncology of the University of Toronto,
R Burkes
J Deslauriers
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机构:Interdepartmental Division of Oncology of the University of Toronto,
J Deslauriers
Y Cormier
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机构:Interdepartmental Division of Oncology of the University of Toronto,
Y Cormier
LD de Bedoya
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机构:Interdepartmental Division of Oncology of the University of Toronto,
LD de Bedoya
J Ottaway
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机构:Interdepartmental Division of Oncology of the University of Toronto,
J Ottaway
K James
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机构:Interdepartmental Division of Oncology of the University of Toronto,
K James
B Zee
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机构:Interdepartmental Division of Oncology of the University of Toronto,
B Zee
机构:
[1] Interdepartmental Division of Oncology of the University of Toronto,
Thirty-one patients with stage IIIA (N2) non-small-cell lung cancer were randomized to receive radiotherapy alone or chemotherapy with cisplatin and vinblastine followed by surgery. Response rates to induction chemotherapy and radiotherapy were 50% and 53.3% respectively. Complete surgical resection was possible for 62.5% of patients. Median survival times were 16.2 and 18.7 months for radiotherapy alone and chemotherapy-surgery respectively (P = Ns), with no long-term improvement in survival seen with combined-modality treatment.
机构:
Duke Univ, Dept Surg, Durham, NC USADuke Univ, Dept Surg, Durham, NC USA
Mayne, Nicholas R.
Lin, Belle K.
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Univ Arizona, Coll Med Phoenix, Phoenix, AZ USADuke Univ, Dept Surg, Durham, NC USA
Lin, Belle K.
Darling, Alice J.
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机构:
Duke Univ, Dept Surg, Durham, NC USADuke Univ, Dept Surg, Durham, NC USA
Darling, Alice J.
Raman, Vignesh
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Duke Univ, Dept Surg, Durham, NC USADuke Univ, Dept Surg, Durham, NC USA
Raman, Vignesh
Patel, Deven C.
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Stanford Univ, Dept Cardiothorac Surg, Stanford, CA 94305 USADuke Univ, Dept Surg, Durham, NC USA
Patel, Deven C.
Liou, Douglas Z.
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机构:
Stanford Univ, Dept Cardiothorac Surg, Stanford, CA 94305 USA
Stanford Hlth Care ValleyCare, Pleasanton, CA USADuke Univ, Dept Surg, Durham, NC USA
Liou, Douglas Z.
D'Amico, Thomas A.
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Duke Univ, Dept Surg, Durham, NC USADuke Univ, Dept Surg, Durham, NC USA
D'Amico, Thomas A.
Yang, Chi-Fu Jeffrey
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机构:
Massachusetts Gen Hosp, Dept Surg, Div Thorac Surg, Boston, MA 02114 USADuke Univ, Dept Surg, Durham, NC USA
机构:
St Michaels Hosp, Li Ka Shing Knowledge Inst, Keenan Res Ctr, Toronto, ON M5B 1X8, Canada
Univ Toronto, Fac Med, Toronto, ON, CanadaSt Michaels Hosp, Li Ka Shing Knowledge Inst, Keenan Res Ctr, Toronto, ON M5B 1X8, Canada
Hicks, Lisa K.
Cheung, Matthew C.
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机构:
Univ Toronto, Fac Med, Toronto, ON, Canada
Sunnybrook Hlth Sci Ctr, Dept Med, Toronto, ON M4N 3M5, CanadaSt Michaels Hosp, Li Ka Shing Knowledge Inst, Keenan Res Ctr, Toronto, ON M5B 1X8, Canada
Cheung, Matthew C.
Ding, Keyue
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机构:
Natl Canc Inst Canada, Clin Trials Grp, Kingston, ON, CanadaSt Michaels Hosp, Li Ka Shing Knowledge Inst, Keenan Res Ctr, Toronto, ON M5B 1X8, Canada
Ding, Keyue
Hasan, Baktiar
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机构:
Natl Canc Inst Canada, Clin Trials Grp, Kingston, ON, CanadaSt Michaels Hosp, Li Ka Shing Knowledge Inst, Keenan Res Ctr, Toronto, ON M5B 1X8, Canada
Hasan, Baktiar
Seymour, Lesley
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机构:
Natl Canc Inst Canada, Clin Trials Grp, Kingston, ON, CanadaSt Michaels Hosp, Li Ka Shing Knowledge Inst, Keenan Res Ctr, Toronto, ON M5B 1X8, Canada
Seymour, Lesley
Le Maitre, Aurelie
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机构:
Natl Canc Inst Canada, Clin Trials Grp, Kingston, ON, CanadaSt Michaels Hosp, Li Ka Shing Knowledge Inst, Keenan Res Ctr, Toronto, ON M5B 1X8, Canada
Le Maitre, Aurelie
Leighl, Natasha B.
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机构:
Univ Toronto, Fac Med, Toronto, ON, Canada
Princess Margaret Hosp, Univ Hlth Network, Toronto, ON M4X 1K9, CanadaSt Michaels Hosp, Li Ka Shing Knowledge Inst, Keenan Res Ctr, Toronto, ON M5B 1X8, Canada
Leighl, Natasha B.
Shepherd, Frances A.
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机构:
Univ Toronto, Fac Med, Toronto, ON, Canada
Princess Margaret Hosp, Univ Hlth Network, Toronto, ON M4X 1K9, CanadaSt Michaels Hosp, Li Ka Shing Knowledge Inst, Keenan Res Ctr, Toronto, ON M5B 1X8, Canada