Further Alkaloids Common to Ants and Frogs: Decahydroquinolines and a Quinolizidine

被引:0
|
作者
Tappey H. Jones
Jeffrey S. T. Gorman
Roy R. Snelling
Jacques H. C. Delabie
Murray S. Blum
H. Martin Garraffo
Poonam Jain
John W. Daly
Thomas F. Spande
机构
[1] Virginia Military Institute,Department of Chemistry
[2] Los Angeles County Museum of Natural History,Divisao de Zoologia, Centro de Pesquesa do Cacau
[3] CEPLAC,Department of Entomology
[4] University of Georgia,Laboratory of Bioorganic Chemistry
[5] National Institute of Diabetes and Digestive and Kidney Diseases,undefined
[6] National Institutes of Health,undefined
来源
Journal of Chemical Ecology | 1999年 / 25卷
关键词
Alkaloids; mass spectrometry; infrared spectroscopy; amphibians; ants; decahydroquinolines; quinolizidines;
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学科分类号
摘要
Three alkaloids—two minor decahydroquinolines (DHQs) and a major quinolizidine—were detected in an extract of a Brazilian myrmicine ant (Solenopsis (Diplorhoptrum) sp. picea group). One DHQ (3) was identical to a known frog-skin alkaloid, cis-195A (cis-5-methyl-2-propyldecahydroquinoline), while the second DHQ, an isomer of 3, designated 195J, was assigned a tentative cis-2-methyl-5-propyldecahydroquinoline structure (2) based on mass and infrared spectra. The third alkaloid proved identical to the frog-skin alkaloid 195C, for which a structure had not been previously proposed. Mass and infrared spectral analysis, including chemical ionization tandem mass spectrometry, indicated a 4-methyl-6-propylquinolizidine structure (1) for 195C. The four possible diastereomers were synthesized and the (6Z,10E)-4-methyl-6-propylquinolizidine diastereomer (1b) was identical to the natural alkaloid. Skin extracts of a population of a Madagascan mantelline frog contained, among other alkaloids, minor amounts of the same alkaloid triad 1–3 with 1 again predominating. The common occurrence of alkaloids 1–3 in both ant and frog supports the hypothesis that ants are a likely dietary source for sequestered frog-skin alkaloids and brings to six, the alkaloid classes common to ant and frog.
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页码:1179 / 1193
页数:14
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