Relationship between self-organization and biological activity of highly diluted solutions of a tetrahydrazide tetrathiacalix[4]arene derivative

In the course of systematic study of self-organization and properties of diluted solutions of biologically active compounds (BACs), an unknown phenomenon has been discovered. Using a complex of physicochemical methods, it has been shown for the first time that diluted aqueous solutions of many BACs in a wide range of calculated concentrations (10–6–10–20 mol/L), prepared by serial tenfold dilution from a stock solution, are self-organized disperse systems in which the disperse phase is represented by nanosized molecular ensembles (up to 400 nm) denominated nanoassociates [1].