Elevated expression of vascular endothelial growth factor (VEGF) 120 in parthenogenetic porcine placentas

被引:0
|
作者
Yang Han
Hongsheng Ouyang
Dongsheng Che
Xianju Chen
Yongye Huang
I. A. Elfaki elhag
Daxin Pang
Zhanjun Li
机构
[1] Jilin University,Jilin Provincial Key Laboratory of Animal Embryo Engineering, College of Animal Science
[2] Jilin Agricultural University,Key Laboratory of Animal Production, Product Quality and Security, Ministry of Education
[3] Kordofan University,Zoology Department, Faculty of Science
来源
Biotechnology Letters | 2014年 / 36卷
关键词
Angiogenesis; Angiopoietin; Parthenogenetic embroyos; Placenta; Vascular endothelial growth factor; Vasculogenesis;
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学科分类号
摘要
Most mammalian parthenogenetic embryos are unable to develop to term due to placental defects, potentially caused by decreased vasculogenesis and angiogenesis of the parthenogenetic placenta. Here we have compared the expression status of vascular endothelial growth factor (VEGF) and angiopoietin family members between normally developing and parthenogenetic porcine placentas. The result showed significantly reduced expression of these genes but elevated expression of VEGF 120 in the parthenogenetic porcine placenta (p < 0.05). We postulate that the abnormal expression levels of VEGF and angiopoietin family members and, especially, the elevated expression of VEGF 120 observed in parthenogenetic porcine placentas are related to the early miscarriage of parthenogenetic embryos in pigs.
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页码:913 / 917
页数:4
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