Elevated expression of vascular endothelial growth factor (VEGF) 120 in parthenogenetic porcine placentas

被引：5
|
作者：
Han, Yang [1 ]
Ouyang, Hongsheng [1 ]
Che, Dongsheng [2 ]
Chen, Xianju [1 ]
Huang, Yongye [1 ]
elhag, I. A. Elfaki [3 ]
Pang, Daxin [1 ]
Li, Zhanjun [1 ]
机构：
[1] Jilin Univ, Coll Anim Sci, Jilin Prov Key Lab Anim Embryo Engn, Changchun 130062, Peoples R China
[2] Jilin Agr Univ, Key Lab Anim Prod Prod Qual & Secur, Minist Educ, Changchun 130118, Peoples R China
[3] Kordofan Univ, Fac Sci, Dept Zool, North Kordofan, Sudan
来源：
BIOTECHNOLOGY LETTERS | 2014年 / 36卷 / 05期
关键词：
Angiogenesis; Angiopoietin; Parthenogenetic embroyos; Placenta; Vascular endothelial growth factor; Vasculogenesis; ANGIOGENESIS; MICE; VASCULOGENESIS; PREGNANCY; VEGF(188); SYSTEM;
D O I：
10.1007/s10529-013-1443-8
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Most mammalian parthenogenetic embryos are unable to develop to term due to placental defects, potentially caused by decreased vasculogenesis and angiogenesis of the parthenogenetic placenta. Here we have compared the expression status of vascular endothelial growth factor (VEGF) and angiopoietin family members between normally developing and parthenogenetic porcine placentas. The result showed significantly reduced expression of these genes but elevated expression of VEGF 120 in the parthenogenetic porcine placenta (p < 0.05). We postulate that the abnormal expression levels of VEGF and angiopoietin family members and, especially, the elevated expression of VEGF 120 observed in parthenogenetic porcine placentas are related to the early miscarriage of parthenogenetic embryos in pigs.
引用
收藏
页码：913 / 917
页数：5
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