Chemotherapy plus Ofatumumab at Standard or Mega dose in relapsed CLL (COSMIC) trial: study protocol for a phase II randomised controlled trial

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作者：
Dena R. Howard
Talha Munir
Anna Hockaday
Andy C. Rawstron
Laura Collett
Jamie B. Oughton
David Allsup
Adrian Bloor
David Phillips
Peter Hillmen
机构：
[1] University of Leeds,Clinical Trials Research Unit, Leeds Institute of Clinical Trials Research
[2] St James’s University Hospital,St James’s Institute of Oncology
[3] St James’s University Hospital,Haematological Malignancy Diagnostic Service, St James’s Institute of Oncology
[4] Hull and East Yorkshire Hospitals NHS Trust,Department of Haematology, Queens Centre for Oncology and Haematology, Castle Hill Hospital
[5] University of Manchester,Department of Haematology, The Christie NHS Foundation Trust
[6] Manchester Academic Health Sciences Centre,undefined
来源：
Trials | / 17卷
关键词：
CLL, Chronic lymphocytic leukaemia; Ofatumumab; FC; Bendamustine; Phase II trial; MRD, Minimal residual disease; Dose selection; Relapsed population; Randomised clinical trial;
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