Kinetic resolution of racemic 3-tert-butyl-3,4-dihydro-2H-[1,4]benzoxazine via acylation with chiral acyl chlorides

被引：0

作者：

S. A. Vakarov

D. A. Gruzdev

E. N. Chulakov

G. L. Levit

V. P. Krasnov

机构：

[1] Ural Branch of the Russian Academy of Sciences,I. Ya. Postovsky Institute of Organic Synthesis

[2] Ural Federal University named after the first President of Russia B. N. Yeltsin,undefined

来源：

Russian Chemical Bulletin | 2019年 / 68卷

关键词：

acylation; heterocyclic amines; enantiomers; stereoselectivity; kinetic resolution;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

A comparative study of the kinetic resolution of racemic 3-tert-butyl-3,4-dihydro-2H-[1,4]-benzoxazine through the acylation by various chiral acyl chlorides was carried out. A preparative method for obtaining enantiomerically pure (S)-3-tert-butyl-3,4-dihydro-2H-[1,4]benzoxazine can be based on the acylation with N-phthaloyl-(S)-phenylalanyl or (R)-2-phenoxypropionyl chlorides, followed by the acid hydrolysis of the corresponding diastereomerically pure amides.

引用

页码：841 / 847

页数：6

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