Effect of zinc deficiency and supplementation on lipid peroxidation of renal tissue in ovariectomized rats

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作者
Abdulkerim Kasim Baltaci
Fusun Sunar
Rasim Mogulkoc
Esma Oztekin
机构
[1] Selcuk University,Department of Physiology, Meram Medical School
[2] Selcuk University,Department of Biochemistry, Meram Medical School
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关键词
Ovariotomy; zinc deficiency and supplementation; malondialdehyde; glutathione;
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摘要
The aim of this study was to investigate how zinc deficiency and supplementation affects lipid peroxidation in the renal tissue in ovariectomized rats. Four study groups were formed with 10 Spraque-Dawley rats each. Two of the groups served as normal and ovariectomized controls; the other two were ovariectomized rats that were zinc deficient and zinc supplemented, respectively. The zinc-deficient ovariectomized rats showed greater renal and plasma lipid peroxidation, as indicated by higher malondialdehyde levels than all other groups (p<0.05). These values were higher in the ovariectomized controls than those of the normal controls and of the ovariectomized, zinc-supplemented groups (p<0.05), which, in, turn, showed no significant differences of their respective renal and plasma malondialdehyde values.
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页码:231 / 239
页数:8
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