OCT4: A penetrant pluripotency inducer

被引：4
|
作者：
Xuecong Wang
Ralf Jauch
机构：
[1] Chinese Academy of Sciences (GIBH),Guangzhou Institutes of Biomedicine and Health
来源：
Cell Regeneration | / 3卷 / 1期
关键词：
OCT4; Cell penetrating peptide; Induced pluripotent stem cells; Reprogramming; Pluripotency;
D O I：
10.1186/2045-9769-3-6
中图分类号：
学科分类号：
摘要：
Native OCT4 protein has the intrinsic ability of crossing cellular membranes to enter cells. This finding could revive efforts to induce pluripotency with proteins replacing nucleic acid-based approaches, and raises the intriguing question as to whether OCT4 can act non-cell-autonomously.
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