IL-21 induces in vivo immune activation of NK cells and CD8+ T cells in patients with metastatic melanoma and renal cell carcinoma

被引：0
|
作者：
Klaus Stensgaard Frederiksen
Dorthe Lundsgaard
Jeremy A. Freeman
Steven D. Hughes
Thomas L. Holm
Birte K. Skrumsager
Andreas Petri
Lasse T. Hansen
Grant A. McArthur
Ian D. Davis
Kresten Skak
机构：
[1] Novo Nordisk A/S,
[2] ZymoGenetics,undefined
[3] Peter MacCallum Cancer Centre,undefined
[4] Austin Health,undefined
[5] Department of Histology and Cancer Pharmacology,undefined
[6] Novo Nordisk A/S,undefined
来源：
Cancer Immunology, Immunotherapy | 2008年 / 57卷
关键词：
Immune activation; IL-21; Cytokines; Immunotherapy;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
页码：1439 / 1449
页数：10
相关论文
共 50 条
  • [31] Membrane bound IL-21 based NK cell feeder cells drive robust expansion and metabolic activation of NK cells
    Ojo, Evelyn O.
    Sharma, Ashish Arunkumar
    Liu, Ruifu
    Moreton, Stephen
    Checkley-Luttge, Mary-Ann
    Gupta, Kalpana
    Lee, Grace
    Lee, Dean A.
    Otegbeye, Folashade
    Sekaly, Rafick-Pierre
    de Lima, Marcos
    Wald, David N.
    SCIENTIFIC REPORTS, 2019, 9 (1)
  • [32] IL-21 Modulates Activation of NKT Cells in Patients with Stage IV Malignant Melanoma
    Coquet, Jonathan M.
    Skak, Kresten
    Davis, Ian D.
    Smyth, Mark J.
    Godfrey, Dale I.
    CLINICAL & TRANSLATIONAL IMMUNOLOGY, 2013, 2
  • [33] IL-21 secreted by APC confers robust expansion of antigen specific CD8+ T cells with distinct phenotype
    Ansen, Sascha
    Butler, Marcus O.
    Berezovskaya, Alla
    Murray, Andrew P.
    Nadler, Lee M.
    Hirano, Naoto
    CANCER RESEARCH, 2006, 66 (08)
  • [34] IL-21 activates CD8+T cells and downregulates Tregs in a B16 melanoma model
    Kim-Schulze, S.
    Fang, J.
    Elliott, B. M.
    Kim, D. W.
    Kaufman, H. L.
    ANNALS OF SURGICAL ONCOLOGY, 2007, 14 (02) : 19 - 20
  • [35] IL-21 activates tumor antigen specific CD8+ T cells and down regulates regulatory T cells in B16 melanomas
    Kim-Schulze, Seunghee
    Kim, Hong Sung
    Fang, Jane
    Kim, Daewon
    Ha, Junghee
    Kaufman, Howard L.
    JOURNAL OF IMMUNOTHERAPY, 2007, 30 (08) : 886 - 887
  • [36] IL-6 promotes the differentiation of a subset of naive CD8+ T cells into IL-21-producing B helper CD8+ T cells
    Yang, Rui
    Masters, April R.
    Fortner, Karen A.
    Champagne, Devin P.
    Yanguas-Casas, Natalia
    Silberger, Daniel J.
    Weaver, Casey T.
    Haynes, Laura
    Rincon, Mercedes
    JOURNAL OF EXPERIMENTAL MEDICINE, 2016, 213 (11): : 2281 - 2291
  • [37] Induction of granulysin in CD8+ T cells by IL-21 and IL-15 is suppressed by human immunodeficiency virus-1
    Hogg, A. E.
    Bowick, G. C.
    Herzog, N. K.
    Cloyd, M. W.
    Endsley, J. J.
    JOURNAL OF LEUKOCYTE BIOLOGY, 2009, 86 (05) : 1191 - 1203
  • [38] Distribution, characterization, and induction of CD8+ regulatory T cells and IL-17-producing CD8+ T cells in nasopharyngeal carcinoma
    Li, Jiang
    Huang, Zhou-feng
    Xiong, Geng
    Mo, Hao-Yuan
    Qiu, Fang
    Mai, Hai-Qiang
    Chen, Qiu-Yan
    He, Jia
    Chen, Shu-peng
    Zheng, Li-Min
    Qian, Chao-Nan
    Zeng, Yi-Xin
    JOURNAL OF TRANSLATIONAL MEDICINE, 2011, 9
  • [39] Distribution, characterization, and induction of CD8+ regulatory T cells and IL-17-producing CD8+ T cells in nasopharyngeal carcinoma
    Jiang Li
    Zhou-Feng Huang
    Geng Xiong
    Hao-Yuan Mo
    Fang Qiu
    Hai-Qiang Mai
    Qiu-Yan Chen
    Jia He
    Shu-peng Chen
    Li-Min Zheng
    Chao-Nan Qian
    Yi-Xin Zeng
    Journal of Translational Medicine, 9
  • [40] AB821 IS A CD8+ T CELL SELECTIVE IL-21 WITH ENHANCED BIOAVAILABILITY THAT MEDIATES POTENT ANTI-TUMOR ACTIVITY, CYTOTOXICITY, AND EXPANSION OF MEMORY CD8+ T CELLS
    Greer, Renee
    Nguyen, Henry
    Mesko, Paul
    Lan, Ruth
    Prior, Wei Wei
    Sultan, Hussein
    Sukthankar, Meghana
    Ni, Irene
    Chin, S. Michael
    Moynihan, Kelly
    Schumacher, Ton
    Schreiber, Robert
    Yeung, Andy
    Djuretic, Ivana
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2022, 10 : A1125 - A1125
12345