CD3ε tunes CAR T cell anticancer activity

被引：0
|
作者：
Alexandra Flemming
机构：
[1] Nature Reviews Immunology,
来源：
Nature Reviews Immunology | 2020年 / 20卷
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学科分类号：
摘要：
Chimeric antigen receptor (CAR) T cell therapies for cancer immunotherapy can lead to excessive cytokine release. Now, a report in Cell shows that inclusion of the CD3ε signalling domain in CAR constructs may restrain cytokine release and improve anti-tumour function.
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页码：520 / 521
页数：1
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