Warburg effect enhanced by AKR1B10 promotes acquired resistance to pemetrexed in lung cancer-derived brain metastasis

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作者
Wenzhe Duan
Wenwen Liu
Shengkai Xia
Yang Zhou
Mengyi Tang
Mingxin Xu
Manqing Lin
Xinyu Li
Qi Wang
机构
[1] Dalian Medical University,Department of Respiratory Medicine, The Second Hospital
[2] Dalian Medical University,Cancer Translational Medicine Research Center, The Second Hospital
[3] Ningbo University,Ningbo Institute of Innovation for Combined Medicine and Engineering, The Affiliated Li Huili Hospital
[4] Dalian Medical University,Department of Neurosurgery, The Second Hospital
关键词
Lung cancer; Brain metastasis; Chemotherapeutic resistance; Pemetrexed; AKR1B10; Warburg metabolism; Histone lactylation;
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