Synthesis and Antioxidant and Anti-Influenza Activity of Aminomethanesulfonic Acids

被引：0

作者：

R. E. Khoma

V. O. Gelmboldt

A. A. Énnan

T. L. Gridina

A. S. Fedchuk

V. P. Lozitsky

I. M. Rakipov

A. S. Vladyka

机构：

[1] Ministry of Education and Science and National Academy of Sciences of Ukraine,Physical

[2] I. I. Mechnikov Odessa National University,Chemical Institute for Environmental and Human Protection

[3] Odessa National Medical University,A. V. Bogatsky Physical

[4] Odessa Research Center Biomedical Testing of Food and Drugs,Chemical Institute

[5] National Academy of Sciences of Ukraine,undefined

来源：

Pharmaceutical Chemistry Journal | 2019年 / 53卷

关键词：

aminomethanesulfonic acids; antioxidant activity; anti-influenza activity; A/Hong Kong/1/68 (H3N2); A/PR/8/34 (H1N1);

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Aminomethanesulfonic acid (I) and its N-methyl- (II), N-(2-hydroxy)ethyl- (III), N-(tert-butyl)- (IV), N-benzyl- (V), and 4-(N-phenylaminomethyl)phenyl- (VI) derivatives (V and VI not previously reported) were synthesized and characterized by elemental analysis and IR and mass spectroscopy. The in vitro antioxidant activities of aminomethanesulfonic acids I-VI were found to be comparatively weak. Compounds IV and V suppressed statistically significantly reproduction of influenza virus strains A/Hong Kong/1/68 (H3N2) and A/PR/8/34 (H1N1) in chorioallantoic membrane tissue culture.

引用

页码：436 / 439

页数：3

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