Synthesis and Antioxidant and Anti-Influenza Activity of Aminomethanesulfonic Acids

被引：0
|
作者：
R. E. Khoma
V. O. Gelmboldt
A. A. Énnan
T. L. Gridina
A. S. Fedchuk
V. P. Lozitsky
I. M. Rakipov
A. S. Vladyka
机构：
[1] Ministry of Education and Science and National Academy of Sciences of Ukraine,Physical
[2] I. I. Mechnikov Odessa National University,Chemical Institute for Environmental and Human Protection
[3] Odessa National Medical University,A. V. Bogatsky Physical
[4] Odessa Research Center Biomedical Testing of Food and Drugs,Chemical Institute
[5] National Academy of Sciences of Ukraine,undefined
来源：
Pharmaceutical Chemistry Journal | 2019年 / 53卷
关键词：
aminomethanesulfonic acids; antioxidant activity; anti-influenza activity; A/Hong Kong/1/68 (H3N2); A/PR/8/34 (H1N1);
D O I：
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中图分类号：
学科分类号：
摘要：
Aminomethanesulfonic acid (I) and its N-methyl- (II), N-(2-hydroxy)ethyl- (III), N-(tert-butyl)- (IV), N-benzyl- (V), and 4-(N-phenylaminomethyl)phenyl- (VI) derivatives (V and VI not previously reported) were synthesized and characterized by elemental analysis and IR and mass spectroscopy. The in vitro antioxidant activities of aminomethanesulfonic acids I-VI were found to be comparatively weak. Compounds IV and V suppressed statistically significantly reproduction of influenza virus strains A/Hong Kong/1/68 (H3N2) and A/PR/8/34 (H1N1) in chorioallantoic membrane tissue culture.
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页码：436 / 439
页数：3
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