Cloning of BNIP3h, a member of proapoptotic BNIP3 family genes

被引：0
|
作者：
Mohammad Farooq
Younghee Kim
Sanguk Im
Eunjung Chung
Sunyoung Hwang
Miyoung Sohn
Moonkyu Kim
Jungchul Kim
机构：
[1] Kyungpook National University School of Medicine,Department of Immunology
来源：
Experimental & Molecular Medicine | 2001年 / 33卷
关键词：
Apoptosis; BNIP3 family proteins; BNIP3h;
D O I：
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中图分类号：
学科分类号：
摘要：
Apoptosis is regulated by interaction of antiapoptotic Bcl-2 family proteins with various proapoptotic proteins, several of which are also members of the Bcl-2 family. BNIP3 (formerly NIP3) is a proapoptotic mitochondrial protein classified in the Bcl-2 family based on limited sequence homology-3 (BH3) domain and COOH-terminal transmembrane domain. Sequence comparison of BNIP3 has indicated that there are several BNIP3 human homologs of this protein, like BNIP3L, Nix and BNIP3. We have cloned a new member of BNIP3 family from the cDNA library prepared from human dermal papilla cells and designated as BNIP3h. BNIP3h shows substantial homology with other BNIP3 family proteins. BNIP3h induced apoptosis from 24 hours after transfection in MCF7 cell lines and its apoptosis inducing activity is extended until 72 hours after transfection.
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页码：169 / 173
页数：4
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