One-step conjugation of glycylglycine with [18F]FDG and a pilot PET imaging study

被引：0

作者：

A. M. Şenışık

Ç. İçhedef

A. Y. Kılçar

E. Uçar

K. Arı

D. Göksoy

Y. Parlak

Bedriye Elvan Sayıt Bilgin

S. Teksöz

机构：

[1] Istanbul Kemerburgaz University,Vocational School of Health Services/Radiotheraphy

[2] Ege University,Department of Nuclear Applications, Institute of Nuclear Sciences

[3] Celal Bayar University,Departmant of Nuclear Medicine

来源：

Journal of Radioanalytical and Nuclear Chemistry | 2018年 / 316卷

关键词：

FDG; Imaging; Glycylglycine; PET; Radiopharmaceuticals;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

This study describes a single step conjugation of Glycylglycine (GlyGly) which is a small peptide, with [18F]FDG via oxime formation. Amiooxy-functionalization of GlyGly (AO-GlyGly) was accomplished through the reaction of Boc-aminooxy succinimide ester. Conjugation reaction was performed at 100 °C for 30 min in a vial containing AO-GlyGly and [18F]FDG solution. The radiolabeled product ([18F]FDG-GlyGly) was obtained with 98.65 ± 0.35% yield without any purification step which makes this method more attractive for 18F radiolabeling. The present study is concluded with an in vivo pilot animal PET study to assess biodistribution and kinetics of chemoselectively [18F]FDG tagged GlyGly in vivo.

引用

页码：457 / 463

页数：6

共 50 条

[41] Radiotherapy volume delineation using dynamic [18F]-FDG PET/CT imaging in patients with oropharyngeal cancer: a pilot study
Antti Silvoniemi
Mueez U Din
Sami Suilamo
Tony Shepherd
Heikki Minn
International Journal of Computer Assisted Radiology and Surgery, 2016, 11 : 2059 - 2069
[42] An improved synthesis of [18F]VAT precursor for a one-step radiofluorination
Hu, Bao
Akula, Hari
Noh, Doyoung
Mui, Yiu-Fung
Slifstein, Mark
Parsey, Ramin
Qu, Wenchao
NUCLEAR MEDICINE AND BIOLOGY, 2022, 108 : S85 - S86
[43] Radiotherapy volume delineation using dynamic [18F]-FDG PET/CT imaging in patients with oropharyngeal cancer: a pilot study
Silvoniemi, Antti
Din, Mueez U.
Suilamo, Sami
Shepherd, Tony
Minn, Heikki
INTERNATIONAL JOURNAL OF COMPUTER ASSISTED RADIOLOGY AND SURGERY, 2016, 11 (11) : 2059 - 2069
[44] [18F]FDG PET and [18F]FP-CIT PET studies in Atypical Parkinsonism
Kim, Su-Jeong
Lee, Chong
MOVEMENT DISORDERS, 2014, 29 : S89 - S89
[45] One-step synthesis of 4-[18F]fluorobenzyltriphenylphosphonium cation for imaging with positron emission tomography
Zhang, Zhengxing
Zhang, Chengcheng
Lau, Joseph
Colpo, Nadine
Benard, Francois
Lin, Kuo-Shyan
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2016, 59 (11): : 467 - 471
[46] Emerging Radiopharmaceuticals in Pet Imaging for Mesothelioma: A Review of [18F]FDG Alternatives
Guglielmo, Priscilla
Crivellaro, Cinzia
Castello, Angelo
Della Corte, Carminia Maria
Pagano, Maria
Marchesi, Silvia
Occhipinti, Mario
Zucali, Paolo Andrea
Evangelista, Laura
MOLECULAR DIAGNOSIS & THERAPY, 2025, 29 (01) : 55 - 66
[47] On the factors affecting the liver SUV in [18F]FDG PET/CT imaging
Laffon, Eric
de Clermont, Henri
Marthan, Roger
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2023, 50 (03) : 650 - 651
[48] Imaging of human supraspinal locomotor centers with [18F]-FDG-PET
La Fougere, Christian
Zwergal, Andreas
Rominger, Axel
Brandt, Thomas
Strupp, Michael
Dieterich, Marianne
Jahn, Klaus
Bartenstein, P.
JOURNAL OF NUCLEAR MEDICINE, 2009, 50
[49] Clinical acceptance of combined [18F] FDG PET/MR dementia imaging
Bresch, Anke
Gertz, Hermann-J
Schoenknecht, Peter
Schroeter, Matthias
Werner, Peter
Tiepolt, Solveig
Fritzsch, Dominik
Hoffmann, Karl
Sabri, Osama
Barthel, Henryk
JOURNAL OF NUCLEAR MEDICINE, 2014, 55
[50] The Place of [18F]FDG PET/BT imaging in bladder cancer patients
Inal, E.
Denizmen, D.
Kiran, M.
Simsek, D. Has
Tantekin, A.
Isik, E.
Erdem, S.
Sanli, O.
Sanli, Y.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2024, 51 : S593 - S593

← 1 2 3 4 5 →