A blooming resolvase at chromosomal fragile sites

被引：0

作者：

Achille Pellicioli

Marco Muzi-Falconi

机构：

[1] Università degli Studi di Milano,Achille Pellicioli and Marco Muzi

[2] Via Celoria 26,Falconi are in the Dipartimento di Bioscienze

[3] 20133 Milano,undefined

[4] Italy,undefined

来源：

Nature Cell Biology | 2013年 / 15卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Common fragile sites (CFSs) are chromosomal regions that are prone to form breaks or gaps during mitosis, in particular following replication stress. The mechanisms modulating CFS expression and promoting safe chromatid transmission to daughter cells are not clear. Now CFS expression is shown to reflect the activity of the MUS81–EME1 resolvase complex which cooperates with the dissolving action of the BLM helicase to prevent uncontrolled chromosome breakage and to promote genome integrity.

引用

页码：883 / 885

页数：2

共 50 条

[41] Probability models and the applicability of statistical procedures in the identification of chromosomal fragile sites
Dahm, PF
Olmsted, AW
Greenbaum, IF
BIOMETRICS, 2002, 58 (04) : 1028 - 1031
[42] CONSISTENT INTERSTITIAL CHROMOSOMAL DELETIONS IN MYELOID MALIGNANCIES AND THEIR CORRELATION WITH FRAGILE SITES
HIRST, WJR
CZEPULKOWSKI, B
MUFTI, GJ
CANCER GENETICS AND CYTOGENETICS, 1993, 65 (01) : 51 - 57
[43] Chromosomal fragile sites and DNA amplification in drug-resistant cells
Kuo, MT
Sen, S
Hittelman, WN
Hsu, TC
BIOCHEMICAL PHARMACOLOGY, 1998, 56 (01) : 7 - 13
[44] FRAGILE SITES AND CHROMOSOMAL STRUCTURAL REARRANGEMENTS IN HUMAN-LEUKEMIA AND CANCER
DEBRAEKELEER, M
ANTICANCER RESEARCH, 1987, 7 (03) : 417 - 422
[45] Increased chromosomal instability at common fragile sites in Seckel syndrome.
Durkin, SG
Casper, AM
Glover, TW
AMERICAN JOURNAL OF HUMAN GENETICS, 2003, 73 (05) : 229 - 229
[46] How common are common fragile sites: Variation of aphidicolin-induced chromosomal fragile sites in a population of the deer mouse (Peromyscus maniculatus)
McAllister, BF
Greenbaum, IF
HUMAN GENETICS, 1997, 100 (02) : 182 - 188
[47] How common are common fragile sites: variation of aphidicolin-induced chromosomal fragile sites in a population of the deer mouse (Peromyscus maniculatus)
B. F. McAllister
I. F. Greenbaum
Human Genetics, 1997, 100 : 182 - 188
[48] Expression of folate sensitive and aphidiecolin induced chromosomal fragile sites in familial neuroblastoma
Ankathil, R
Kasumakumary, P
Priyakumary, T
Nair, MK
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2002, 21 (03) : 383 - 388
[49] Variation of aphidicolin-induced chromosomal fragile sites in a population of deer mice
Greenbaum, IF
McAllister, BF
CYTOGENETICS AND CELL GENETICS, 1996, 74 (04): : 306 - 306
[50] ASSOCIATION BETWEEN CUTIS-VERTICIS-GYRATA AND CHROMOSOMAL FRAGILE SITES - REPLY
MUSUMECI, SA
AMERICAN JOURNAL OF MEDICAL GENETICS, 1992, 44 (01): : 120 - 120

← 1 2 3 4 5 →