A blooming resolvase at chromosomal fragile sites

被引：0
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作者：
Achille Pellicioli
Marco Muzi-Falconi
机构：
[1] Università degli Studi di Milano,Achille Pellicioli and Marco Muzi
[2] Via Celoria 26,Falconi are in the Dipartimento di Bioscienze
[3] 20133 Milano,undefined
[4] Italy,undefined
来源：
Nature Cell Biology | 2013年 / 15卷
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摘要：
Common fragile sites (CFSs) are chromosomal regions that are prone to form breaks or gaps during mitosis, in particular following replication stress. The mechanisms modulating CFS expression and promoting safe chromatid transmission to daughter cells are not clear. Now CFS expression is shown to reflect the activity of the MUS81–EME1 resolvase complex which cooperates with the dissolving action of the BLM helicase to prevent uncontrolled chromosome breakage and to promote genome integrity.
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页码：883 / 885
页数：2
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