Linking oncogenic pathways with therapeutic opportunities

被引：0
|
作者：
Andrea H. Bild
Anil Potti
Joseph R. Nevins
机构：
[1] the Duke Institute for Genome Sciences and Policy,
[2] Duke University Medical Center,undefined
来源：
Nature Reviews Cancer | 2006年 / 6卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Multiple mutations and alterations in the cancer genome lead to the deregulation of various cell-signalling pathways that control cell function. Can molecular-profiling studies be used to fully understand this complexity and provide an opportunity to link pathway deregulation with potential therapeutic strategies?
引用
收藏
页码：735 / 741
页数：6
相关论文
共 50 条
  • [41] TGF-β Modulated Pathways in Colorectal Cancer: New Potential Therapeutic Opportunities
    Fasano, Morena
    Pirozzi, Mario
    Miceli, Chiara Carmen
    Cocule, Mariateresa
    Caraglia, Michele
    Boccellino, Mariarosaria
    Vitale, Pasquale
    De Falco, Vincenzo
    Farese, Stefano
    Zotta, Alessia
    Ciardiello, Fortunato
    Addeo, Raffaele
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2024, 25 (13)
  • [42] Oxidative stress pathways as new therapeutic opportunities: from infection to lung ageing
    Ito, K.
    ACTA PHYSIOLOGICA, 2014, 211 : 30 - 30
  • [43] Targeting signal transduction pathways of cancer stem cells for therapeutic opportunities of metastasis
    Iqbal, Waqas
    Alkarim, Saleh
    AlHejin, Ahmed
    Mukhtar, Hasan
    Saini, Kulvinder S.
    ONCOTARGET, 2016, 7 (46) : 76337 - 76353
  • [44] Oncogenic Neuregulin 1 gene (NRG1) fusions in cancer: A potential new therapeutic opportunities
    Zhang, Congwang
    Mei, Wuxuan
    Zeng, Changchun
    BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2022, 1877 (03):
  • [45] Oncogenic KRAS-Induced Feedback Inflammatory Signaling in Pancreatic Cancer: An Overview and New Therapeutic Opportunities
    Bansod, Sapana
    Dodhiawala, Paarth B.
    Lim, Kian-Huat
    CANCERS, 2021, 13 (21)
  • [46] Sphingolipid/Ceramide Pathways and Autophagy in the Onset and Progression of Melanoma: Novel Therapeutic Targets and Opportunities
    Lai, Michele
    La Rocca, Veronica
    Amato, Rachele
    Freer, Giulia
    Pistello, Mauro
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019, 20 (14)
  • [47] Recent advances in cancer-associated fibroblast: Biomarkers, signaling pathways, and therapeutic opportunities
    Zhou Donger
    Zheng Lei
    中华医学杂志英文版, 2024, 137 (06)
  • [48] Obesity, metabolic dysfunction, and cardiac fibrosis: pathophysiological pathways, molecular mechanisms, and therapeutic opportunities
    Cavalera, Michele
    Wang, Junhong
    Frangogiannis, Nikolaos G.
    TRANSLATIONAL RESEARCH, 2014, 164 (04) : 323 - 335
  • [49] Recent advances in cancer-associated fibroblast: Biomarkers, signaling pathways, and therapeutic opportunities
    Zhou, Donger
    Zheng, Lei
    CHINESE MEDICAL JOURNAL, 2024, 137 (06) : 638 - 650
  • [50] Costimulatory Pathways in Kidney Transplantation: Pathogenetic Role, Clinical Significance and New Therapeutic Opportunities
    Esposito, Pasquale
    Grosjean, Fabrizio
    Rampino, Teresa
    Libetta, Carmelo
    Gregorini, Marilena
    Fasoli, Gianluca
    Marchi, Gianluca
    Sileno, Giuseppe
    Montagna, Francesca
    Dal Canton, Antonio
    INTERNATIONAL REVIEWS OF IMMUNOLOGY, 2014, 33 (03) : 212 - 233
12345