Anti-inflammatory protein TSG-6 secreted by bone marrow mesenchymal stem cells attenuates neuropathic pain by inhibiting the TLR2/MyD88/NF-κB signaling pathway in spinal microglia

被引：0
|
作者：
Hao Yang
Lingmin Wu
Huimin Deng
Yuanli Chen
Huanping Zhou
Meiyun Liu
Shaochen Wang
Li Zheng
Lina Zhu
Xin Lv
机构：
[1] Tongji University School of Medicine,Department of Anesthesiology, Shanghai Pulmonary Hospital
[2] The first Hospital of Anhui Medical University,Department of Anesthesiology
[3] Fuyang Hospital of Anhui Medical University,Department of Anesthesiology
来源：
Journal of Neuroinflammation | / 17卷
关键词：
Neuropathic pain; BMSCs; TSG-6; Neuroinflammation; TLR2; Microglia;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 36 条
  • [21] A glucan from Ganoderma lucidum: Structural characterization and the anti-inflammatory effect on Parkinson's disease via regulating dysfunctions of intestinal microecology and inhibiting TLR4/MyD88/NF-κB signaling pathway
    Chen, Li
    Ling, Yingjie
    Sun, Jiaxin
    Zhou, Shuo
    Xiao, Yao
    Zou, Xinyu
    Yang, Xiudong
    Zhang, Yan
    JOURNAL OF ETHNOPHARMACOLOGY, 2025, 343
  • [22] Platycodin D inhibits MPP+-induced inflammatory response in BV-2 cells through the TLR4/MyD88/NF-κB signaling pathway
    Sun, Fu
    Liu, Fengguo
    JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION, 2020, 40 (05) : 479 - 485
  • [23] Mahonia bealei (Fort.) Carr. Leaf extract modulates the TLR2/MyD88/NF-κB signaling pathway to inhibit PGN-induced inflammation in RAW264.7 cells
    Wei, Liang
    Ma, Wenjun
    Liu, Shangwei
    Mi, Shengcheng
    Shen, Qiong
    Lu, Qi
    Liu, Zhangguo
    JOURNAL OF ETHNOPHARMACOLOGY, 2025, 344
  • [24] Amentoflavone Exerts Anti-Neuroinflammatory Effects by Inhibiting TLR4/MyD88/NF-κB and Activating Nrf2/HO-1 Pathway in Lipopolysaccharide-Induced BV2 Microglia
    Rong, Shikuo
    Yang, Chunrong
    Wang, Feng
    Wu, Yiyang
    Sun, Kuishen
    Sun, Tao
    Wu, Zeyu
    MEDIATORS OF INFLAMMATION, 2022, 2022
  • [25] Surfactin attenuates particulate matter-induced COX-2-dependent PGE2 production in human gingival fibroblasts by inhibiting TLR2 and TLR4/MyD88/NADPH oxidase/ROS/PI3K/Akt/NF-κB signaling pathway
    Thi Thuy Tien Vo
    Wee, Yinshen
    Chen, Yuh-Lien
    Cheng, Hsin-Chung
    Vo Phuoc Tuan
    Lee, I-Ta
    JOURNAL OF PERIODONTAL RESEARCH, 2021, 56 (06) : 1185 - 1199
  • [26] Exploring the Anti-Inflammatory Effect of Tryptanthrin by Regulating TLR4/MyD88/ROS/NF-κB, JAK/STAT3, and Keap1/Nrf2 Signaling Pathways
    Zhu, Jie
    Cheng, Wen
    He, Tian-Tian
    Hou, Bao-Long
    Lei, Li-Yan
    Wang, Zheng
    Liang, Yan-Ni
    ACS OMEGA, 2024, 9 (28): : 30904 - 30918
  • [27] Bone marrow mesenchymal stem cells alleviate stress-induced hyperalgesia via restoring gut microbiota and inhibiting neuroinflammation in the spinal cord by targeting the AMPK/NF-ΚB signaling pathway
    Tan, Xi
    Wang, Danning
    Lu, Pei
    Guan, Shaodi
    Zheng, Quanjing
    Du, Xiaoyi
    Xu, Hui
    LIFE SCIENCES, 2023, 314
  • [28] A Novel 1,8-Naphthyridine-2-Carboxamide Derivative Attenuates Inflammatory Responses and Cell Migration in LPS-Treated BV2 Cells via the Suppression of ROS Generation and TLR4/Myd88/NF-κB Signaling Pathway
    Nguyen, Phuong Linh
    Bui, Bich Phuong
    Lee, Heesoon
    Cho, Jungsook
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (05) : 1 - 19
  • [29] TLR4-IN-C34 Inhibits Lipopolysaccharide-Stimulated Inflammatory Responses via Downregulating TLR4/MyD88/NF-κB/NLRP3 Signaling Pathway and Reducing ROS Generation in BV2 Cells
    Zhang, Shan-Shan
    Liu, Man
    Liu, Dong-Ni
    Yang, Ying-Lin
    Du, Guan-Hua
    Wang, Yue-Hua
    INFLAMMATION, 2022, 45 (02) : 838 - 850
  • [30] TLR4-IN-C34 Inhibits Lipopolysaccharide-Stimulated Inflammatory Responses via Downregulating TLR4/MyD88/NF-κB/NLRP3 Signaling Pathway and Reducing ROS Generation in BV2 Cells
    Shan-Shan Zhang
    Man Liu
    Dong-Ni Liu
    Ying-Lin Yang
    Guan-Hua Du
    Yue-Hua Wang
    Inflammation, 2022, 45 : 838 - 850
1234