The effect of high-fat diet on the development of obesity and serum leptin level in rats

被引：0
|
作者：
Bahceci M. [1 ]
Tuzcu A. [1 ]
Akkus M. [2 ]
Yaldiz M. [3 ]
Ozbay A. [4 ]
机构：
[1] University of Dicle, School of Medicine, Departments of Endocrinology and Metabolism
[2] University of Dicle, School of Medicine, Department of Histology and Embryology
[3] University of Dicle, School of Medicine, Department of Pathology
[4] University of Dicle, School of Medicine, Department of internal Medicine
来源：
Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity | 1999年 / 4卷 / 3期
关键词：
High-fat diet; Leptin; Lipid profile; Obesity;
D O I：
10.1007/BF03339728
中图分类号：
学科分类号：
摘要：
Ten male Wistar-albino rats were overfed with high-fat diet (margarine at the dose 40 g/kg body weight/day in addition to standard rat diet) during six months from the age of between 8-12 weeks. Ten male rats received a standard chow for the same period. The body weights of the overfed rats increased time dependently (basal 171.5±5, at sixth month 268±19 g), whereas those of the rats fed with standard chow did not increase significantly (basal 177±6.4, at sixth month 220±10 g). At the sixth month, mean body fat percentages were 36.3±6.7% and 24.2±5.4% respectively. Both total cholesterol-triglyceride levels and mean serum leptin levels were also higher than in the overfed rats (p<0.01 and p<0.05 respectively). The livers of all rats were histopathologically normal. Conclusion: high-fat diet resulting in an increased body fat percentage in rats is associated with hyperleptinemia, hypercholesterolemia and hypertriglyceridemia. © 1999, Editrice Kurtis.
引用
收藏
页码：128 / 132
页数：4
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