Octanoic Acid Suppresses Harmaline-Induced Tremor in Mouse Model of Essential Tremor

被引：0
|
作者：
Fatta B. Nahab
Adrian Handforth
Tyler Brown
Christopher Shin
Arnulfo Quesada
Chuanhui Dong
Dietrich Haubenberger
Mark Hallett
机构：
[1] University of Miami Miller School of Medicine,Department of Neurology
[2] Neurology Service,Research Service, Veterans Affairs Greater Los Angeles Healthcare System, and Department of Neurobiology, David Geffen School of Medicine
[3] Veterans Affairs Greater Los Angeles Healthcare System,Department of Neurology
[4] Research Service,undefined
[5] Veterans Affairs Greater Los Angeles Healthcare System,undefined
[6] University of California at Los Angeles,undefined
[7] Medical University of Vienna,undefined
[8] Human Motor Control Section,undefined
[9] Medical Neurology Branch,undefined
[10] NINDS/NIH,undefined
来源：
Neurotherapeutics | 2012年 / 9卷
关键词：
1-octanol; Octanoic acid; Essential tremor; Harmaline; Therapeutics;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Recent work exploring the use of high-molecular weight alcohols to treat essential tremor (ET) has identified octanoic acid as a potential novel tremor-suppressing agent. We used an established harmaline-based mouse model of ET to compare tremor suppression by 1-octanol and octanoic acid. The dose-related effect on digitized motion power within the tremor bandwidth as a fraction of overall motion power was analyzed. Both 1-octanol and octanoic acid provided significant reductions in harmaline tremor. An 8-carbon alkyl alcohol and carboxylic acid each suppress tremor in a pre-clinical mouse model of ET. Further studies are warranted to determine the safety and efficacy of such agents in humans with ET.
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收藏
页码：635 / 638
页数：3
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