Octanoic Acid Suppresses Harmaline-Induced Tremor in Mouse Model of Essential Tremor

被引：10
|
作者：
Nahab, Fatta B. [1 ]
Handforth, Adrian [2 ]
Brown, Tyler [1 ,6 ]
Shin, Christopher [3 ]
Quesada, Arnulfo [3 ,4 ]
Dong, Chuanhui [1 ]
Haubenberger, Dietrich [5 ,6 ]
Hallett, Mark [6 ]
机构：
[1] Univ Miami, Miller Sch Med, Dept Neurol, Miami, FL 33136 USA
[2] Vet Affairs Greater Los Angeles Healthcare Syst, Neurol Serv, Los Angeles, CA 90073 USA
[3] Vet Affairs Greater Los Angeles Healthcare Syst, Res Serv, Los Angeles, CA 90073 USA
[4] Univ Calif Los Angeles, Dept Neurobiol, David Geffen Sch Med, Los Angeles, CA 90073 USA
[5] Med Univ Vienna, Dept Neurol, Vienna, Austria
[6] NINDS, Human Motor Control Sect, Med Neurol Branch, Bethesda, MD 20892 USA
来源：
NEUROTHERAPEUTICS | 2012年 / 9卷 / 03期
关键词：
1-octanol; Octanoic acid; Essential tremor; Harmaline; Therapeutics; OPEN-LABEL; 1-OCTANOL;
D O I：
10.1007/s13311-012-0121-1
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Recent work exploring the use of high-molecular weight alcohols to treat essential tremor (ET) has identified octanoic acid as a potential novel tremor-suppressing agent. We used an established harmaline-based mouse model of ET to compare tremor suppression by 1-octanol and octanoic acid. The dose-related effect on digitized motion power within the tremor bandwidth as a fraction of overall motion power was analyzed. Both 1-octanol and octanoic acid provided significant reductions in harmaline tremor. An 8-carbon alkyl alcohol and carboxylic acid each suppress tremor in a pre-clinical mouse model of ET. Further studies are warranted to determine the safety and efficacy of such agents in humans with ET.
引用
收藏
页码：635 / 638
页数：4
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