The clinical implications of medulloblastoma subgroups

Medulloblastoma, once thought to represent a single disease entity, is now recognized to comprise distinct subgroups that can be identified using histological, genetic and transcriptomic approaches. Northcott et al. present the evidence for the four recently defined subgroups of medulloblastoma, and highlight how stratification of tumours into these subgroups could have important clinical implications for patient prognosis, treatment and care.