Three-dimensional gradient porous polymeric composites for osteochondral regeneration

被引：0
|
作者：
Elnaz Tamjid
Shadi Marzooghi
Parvin Najafi
Mehrdad Behmanesh
机构：
[1] Tarbiat Modares University,Department of Nanobiotechnology, Faculty of Biological Sciences
[2] Tarbiat Modares University,Department of Biomaterials, Faculty of Interdisciplinary Science and Technology
[3] Tarbiat Modares University,Department of Genetics, Faculty of Biological Sciences
来源：
Journal of Polymer Research | 2022年 / 29卷
关键词：
Gradient pore structure; Additive manufacturing; Geometrical stimulation, Osteochondral engineering;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Poly (ε-caprolactone, PCL) matrix composite scaffolds with controlled gradient pore structure (GPS) were prepared by 3D printing. It is shown that GPS stimulates the osteogenic and chondrogenic differentiation of mesenchymal stem cells (MSCs) in vitro. Curvature-assisted biomineralization and the effect of pore sizes are elaborated. Different effects of nanobioceramics (Bioglass and Titania) on the cell differentiation and tissue-ingrowth kinetics are reported. The fabricated GPS biomaterials by additive manufacturing could provide a new pathway for osteochondral regeneration.
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