Whole-genome fingerprint of the DNA methylome during human B cell differentiation

被引：0

作者：

Marta Kulis

Angelika Merkel

Simon Heath

Ana C Queirós

Ronald P Schuyler

Giancarlo Castellano

Renée Beekman

Emanuele Raineri

Anna Esteve

Guillem Clot

Néria Verdaguer-Dot

Martí Duran-Ferrer

Nuria Russiñol

Roser Vilarrasa-Blasi

Simone Ecker

Vera Pancaldi

Daniel Rico

Lidia Agueda

Julie Blanc

David Richardson

Laura Clarke

Avik Datta

Marien Pascual

Xabier Agirre

Felipe Prosper

Diego Alignani

Bruno Paiva

Gersende Caron

Thierry Fest

Marcus O Muench

Marina E Fomin

Seung-Tae Lee

Joseph L Wiemels

Alfonso Valencia

Marta Gut

Paul Flicek

Hendrik G Stunnenberg

Reiner Siebert

Ralf Küppers

Ivo G Gut

Elías Campo

José I Martín-Subero

机构：

[1] Institut d'Investigacions Biomédiques August Pi i Sunyer (IDIBAPS),Department of Anatomic Pathology

[2] Pharmacology and Microbiology,Department of Laboratory Medicine

[3] University of Barcelona,Department of Laboratory Medicine

[4] Centro Nacional de Análisis Genómico (CNAG),Department of Epidemiology and Biostatistics

[5] Parc Científic de Barcelona,undefined

[6] Structural Biology and Biocomputing Program,undefined

[7] Spanish National Cancer Research Centre (CNIO),undefined

[8] Spanish National Bioinformatics Institute,undefined

[9] European Molecular Biology Laboratory–European Bioinformatics Institute (EMBL-EBI),undefined

[10] Wellcome Trust Genome Campus,undefined

[11] Area de Oncología,undefined

[12] Centro de Investigación Médica Aplicada (CIMA),undefined

[13] Universidad de Navarra,undefined

[14] Servicio de Hematología,undefined

[15] Clínica Universidad de Navarra,undefined

[16] Flow Cytometry Core,undefined

[17] Centro de Investigación Médica Aplicada (CIMA),undefined

[18] Universidad de Navarra,undefined

[19] Université de Rennes 1,undefined

[20] INSERM U917,undefined

[21] Hematology Laboratory,undefined

[22] University Hospital of Rennes,undefined

[23] Blood Systems Research Institute,undefined

[24] University of California,undefined

[25] San Francisco,undefined

[26] Yonsei University College of Medicine,undefined

[27] University of California,undefined

[28] San Francisco,undefined

[29] Molecular Biology,undefined

[30] Nijmegen Centre for Molecular Life Sciences (NCMLS),undefined

[31] Faculties of Science and Medicine,undefined

[32] Radboud University,undefined

[33] Institute of Human Genetics,undefined

[34] Christian Albrechts University,undefined

[35] Institute of Cell Biology (Cancer Research),undefined

[36] Medical School,undefined

[37] University of Duisburg-Essen,undefined

来源：

Nature Genetics | 2015年 / 47卷

关键词：

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中图分类号：

学科分类号：

摘要：

José Martín-Subero and colleagues report the whole-genome bisulfite sequencing of ten blood cell subpopulations representing the cellular stages during B cell differentiation. They find that early stages are characterized by enhancer demethylation and that neoplasms derived from B cell lineages undergo methylation changes in regions with dynamic methylation during normal differentiation.

引用

页码：746 / 756

页数：10

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