2,1-Benzothiazine 2,2-Dioxides. 8*. Synthesis and Structure of 2'-Amino-2-Oxo-1,2-Dihydro-6'H-Spiro-[Indole-3,4'-Pyrano[3,2-c][2,1]Benzothiazine]-3'-Carbonitrile 5',5'-Dioxides

被引：0
|
作者：
I. V. Ukrainets
L. A. Petrushova
N. L. Bereznyakova
Liu Yangyang
机构：
[1] National University of Pharmacy,
[2] Changchun Medical College,undefined
来源：
Chemistry of Heterocyclic Compounds | 2014年 / 50卷
关键词：
1; -2,1-benzothiazin-4(3; )-one 2,2-dioxide; isatin; malononitrile; pyrano[3,2-; ]benzothiazine; spiro[indole-3,4'-pyran];
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摘要：
2,2-Dioxides of 1-R-1H-2,1-benzothiazin-4(3H)-ones easily undergo a three-component condensation with N-substituted isatins and malononitrile in the presence of triethylamine giving 6'-R-1-R1-2'-amino-2-oxo-1,2-dihydro-6'H-spiro[indole-3,4'-pyrano[3,2-c][2,1]benzothiazine]-3'-carbonitrile 5',5'-dioxides in good yields. The reaction with 1-unsubstituted 1H-2,1-benzothiazin-4(3H)-one 2,2-dioxide follows an analogous route, but the products are triethylammonium salts of the corresponding spiro compounds.
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页码：1346 / 1353
页数：7
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