Isoquinoline Alkaloids from Whole Plants of Thalictrum cirrhosum and Their Antirotavirus Activity

被引：2
|
作者：
Dian Luo
Na Lv
Li-Jun Zhu
Ling-Min Liao
Yong Xu
Jin Wang
Wei-Song Kong
Hai-Tao Huang
Min Zhou
Guang-Yu Yang
Qiu-Fen Hu
Xiao-Xi Si
机构：
[1] Yunnan Minzu University,Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education
[2] China Tobacco Yunnan Industrial Co.,Key Laboratory of Tobacco Chemistry of Yunnan Province
[3] Ltd.,undefined
来源：
Chemistry of Natural Compounds | 2020年 / 56卷
关键词：
isoquinoline alkaloids; antirotavirus activity;
D O I：
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中图分类号：
学科分类号：
摘要：
Two new (1 and 2), together with two known (3 and 4), isoquinoline alkaloids were isolated from the whole plants of Thalictrum cirrhosum. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1–4 were tested for their antirotavirus activity. The results revealed that compounds 2 exhibited high antirotavirus activity with a therapeutic index (TI) value of 19.3. This value is close to that of positive control (TI value 20.4). Compounds 1, 3, and 4 also exhibited potent antirotavirus activity with TI value above 10.
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页码：504 / 508
页数：4
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