Targeting of BMI-1 with PTC-209 shows potent anti-myeloma activity and impairs the tumour microenvironment

被引:0
|
作者
Arnold Bolomsky
Karin Schlangen
Wolfgang Schreiner
Niklas Zojer
Heinz Ludwig
机构
[1] Department of Medicine I,Wilhelminen Cancer Research Institute
[2] Wilhelminenspital,Center for Medical Statistics, Informatics and Intelligent Systems
[3] Medical University of Vienna,undefined
关键词
Multiple myeloma; BMI-1; PTC-209; Microenvironment;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 36 条
  • [11] Bmi-1抑制剂PTC-209减轻自身免疫关节炎模型小鼠炎症及骨侵蚀
    林诗雨
    顾鑫
    王芳
    谈文峰
    中国药物与临床, 2021, 21 (20) : 3357 - 3360+3505
  • [12] The first-in-class BMI-1 modulators PTC-028 and PTC596 display potent activity in pre-clinical models of multiple myeloma
    Bolomsky, Arnold
    Muller, Josephine
    Lejeune, Margaux
    Arnold, Dominik
    Duray, Elodie
    Breid, Helene
    Vrancken, Louise
    Hubl, Wolfgang
    Zojer, Niklas
    Caers, Jo
    Ludwig, Heinz
    CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2019, 19 (10): : E113 - E114
  • [13] LP-118, a Novel BCL2 Inhibitor, Shows Potent in Vitro Anti-Myeloma Activity
    Fonseca, Rodrigo
    Zhu, Yuan Xiao
    Bergsagel, P. Leif
    Chesi, Marta
    Pandey, Akhilesh
    Mangalaparthi, Kiran
    Chen, Yi
    Tan, Felai
    Anthony, Stephen P.
    Chen, Yu
    Shen, Yue
    Dai, Bing
    Braggio, Esteban
    Fonseca, Rafael
    BLOOD, 2022, 140 : 7129 - 7130
  • [14] A novel phosphoramide compound, DCZ0805, shows potent anti-myeloma activity via the NF-κB pathway
    Xuejie Gao
    Bo Li
    Anqi Ye
    Houcai Wang
    Yongsheng Xie
    Dandan Yu
    Zhijian Xu
    Bingqing Shi
    Hui Zhang
    Qilin Feng
    Ke Hu
    Yong Zhang
    Cheng Huang
    Guang Yang
    Jumei Shi
    Weiliang Zhu
    Cancer Cell International, 21
  • [15] Targeting BMI-1 with PLGA–PEG nanoparticle-containing PTC209 modulates the behavior of human glioblastoma stem cells and cancer cells
    Elham Poonaki
    Fatemeh Ariakia
    Mohammad Jalili-Nik
    Mehdi Shafiee Ardestani
    Gholamhossein Tondro
    Fariborz Samini
    Sepideh Ghasemi
    Sajad Sahab-Negah
    Ali Gorji
    Cancer Nanotechnology, 2021, 12
  • [16] Bmi-1小分子抑制剂PTC-209对肾癌细胞生物学行为的影响及机制
    区景运
    谭晓军
    胡波
    刘璠娜
    尹良红
    山东医药, 2019, (14) : 27 - 30
  • [17] A novel phosphoramide compound, DCZ0805, shows potent anti-myeloma activity via the NF-κB pathway
    Gao, Xuejie
    Li, Bo
    Ye, Anqi
    Wang, Houcai
    Xie, Yongsheng
    Yu, Dandan
    Xu, Zhijian
    Shi, Bingqing
    Zhang, Hui
    Feng, Qilin
    Hu, Ke
    Zhang, Yong
    Huang, Cheng
    Yang, Guang
    Shi, Jumei
    Zhu, Weiliang
    CANCER CELL INTERNATIONAL, 2021, 21 (01)
  • [18] Targeting BMI-1 with PLGA-PEG nanoparticle-containing PTC209 modulates the behavior of human glioblastoma stem cells and cancer cells
    Poonaki, Elham
    Ariakia, Fatemeh
    Jalili-Nik, Mohammad
    Ardestani, Mehdi Shafiee
    Tondro, Gholamhossein
    Samini, Fariborz
    Ghasemi, Sepideh
    Sahab-Negah, Sajad
    Gorji, Ali
    CANCER NANOTECHNOLOGY, 2021, 12 (01)
  • [19] Cell death-inducing ICAM-1 antibody has broad and potent anti-myeloma activity in vivo
    Veitonmaki, Niina
    Hansson, Markus
    Li, Zhan-chun
    Ljungars, Anne
    Danielsson, Lena
    Bjorn, Frendeus
    CANCER RESEARCH, 2011, 71
  • [20] Anti-bacterial and anti-viral nanchangmycin displays anti-myeloma activity by targeting Otub1 and c-Maf
    Yujia Xu
    Tong Sun
    Kun Zeng
    Min Xu
    Jinhao Chen
    Xiaofeng Xu
    Zubin Zhang
    Biyin Cao
    Xiaowen Tang
    Depei Wu
    Yan Kong
    Yuanying Zeng
    Xinliang Mao
    Cell Death & Disease, 11