A mixed-model approach for genome-wide association studies of correlated traits in structured populations

被引：0
|
作者：
Arthur Korte
Bjarni J Vilhjálmsson
Vincent Segura
Alexander Platt
Quan Long
Magnus Nordborg
机构：
[1] Gregor Mendel Institute,Department of Molecular and Computational Biology
[2] Austrian Academy of Sciences,undefined
[3] University of Southern California,undefined
[4] Institut National de la Recherche Agronomique (INRA),undefined
[5] UR0588,undefined
来源：
Nature Genetics | 2012年 / 44卷
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学科分类号：
摘要：
Magnus Nordborg and colleagues report a parameterized multi-trait mixed model (MTMM) method applied to genome-wide association studies of correlated phenotypes. They test this approach, using both human and Arabidopsis thaliana data sets, and demonstrate how it can be used to identify pleiotropic loci and gene by environment interactions.
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页码：1066 / 1071
页数：5
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