Vascular bioactivation of nitroglycerin: reaction mechanism revealed by crystal structure of aldehyde dehydrogenase-2

被引:0
|
作者
Barbara S Lang
Antonius CF Gorren
Gustav Oberdorfer
M Verena Wenzl
Cristina M Furdui
Leslie B Poole
Bernd Mayer
Karl Gruber
机构
[1] University of Graz,Department of Pharmacology and Toxicology, Institute of Pharmaceutical Sciences
[2] University of Graz,Institute of Molecular Biosciences
[3] Wake Forest School of Medicine,Department of Internal Medicine, Section of Molecular Medicine
[4] Wake Forest School of Medicine,Department of Biochemistry
关键词
Nitric Oxide; Hydrogen Bond; Aldehyde; Active Metabolite; Nitroglycerin;
D O I
10.1186/2050-6511-13-S1-A37
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 50 条
  • [1] Vascular Bioactivation of Nitroglycerin by Aldehyde Dehydrogenase-2 REACTION INTERMEDIATES REVEALED BY CRYSTALLOGRAPHY AND MASS SPECTROMETRY
    Lang, Barbara S.
    Gorren, Antonius C. F.
    Oberdorfer, Gustav
    Wenzl, M. Verena
    Furdui, Cristina M.
    Poole, Leslie B.
    Mayer, Bernd
    Gruber, Karl
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 287 (45) : 38124 - 38134
  • [2] Vascular Bioactivation of Nitroglycerin Is Catalyzed by Cytosolic Aldehyde Dehydrogenase-2
    Beretta, Matteo
    Woelkart, Gerald
    Schernthaner, Michaela
    Griesberger, Martina
    Neubauer, Regina
    Schmidt, Kurt
    Sacherer, Michael
    Heinzel, Frank R.
    Kohlwein, Sepp D.
    Mayer, Bernd
    [J]. CIRCULATION RESEARCH, 2012, 110 (03) : 385 - U52
  • [3] Bioactivation of nitroglycerin is determined by the subcellular localization of aldehyde dehydrogenase-2
    Regina Neubauer
    Corina Madreiter
    Matteo Beretta
    Gerald Wölkart
    Kurt Schmidt
    Astrid Schrammel
    Bernd Mayer
    [J]. BMC Pharmacology and Toxicology, 13 (Suppl 1)
  • [4] Formation of Nitric Oxide by Aldehyde Dehydrogenase-2 Is Necessary and Sufficient for Vascular Bioactivation of Nitroglycerin
    Opelt, Marissa
    Eroglu, Emrah
    Waldeck-Weiermair, Markus
    Russwurm, Michael
    Koesling, Doris
    Malli, Roland
    Graier, Wolfgang F.
    Fassett, John T.
    Schrammel, Astrid
    Mayer, Bernd
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2016, 291 (46) : 24076 - 24084
  • [5] Potent Inhibition of Aldehyde Dehydrogenase-2 by Diphenyleneiodonium: Focus on Nitroglycerin Bioactivation
    Neubauer, Regina
    Neubauer, Andrea
    Woelkart, Gerald
    Schwarzenegger, Christine
    Lang, Barbara
    Schmidt, Kurt
    Russwurm, Michael
    Koesling, Doris
    Gorren, Antonius C. F.
    Schrammel, Astrid
    Mayer, Bernd
    [J]. MOLECULAR PHARMACOLOGY, 2013, 84 (03) : 407 - 414
  • [6] Cytosolic expression of aldehyde dehydrogenase-2 is essential for nitroglycerin bioactivation by cultured cells
    Neubauer, Regina
    Beretta, Matteo
    Schrammel, Astrid
    Schmidt, Kurt
    Mayer, Bernd
    [J]. NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 2012, 27 : S21 - S21
  • [7] Aldehyde dehydrogenase-2 independent bioactivation of nitroglycerin in porcine and bovine coronary arteries
    Neubauer, Regina
    Woelkart, Gerald
    Opelt, Marissa
    Kollau, Alexander
    Neubauer, Andrea
    Schrammel, Astrid
    Mayer, Bernd
    [J]. NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 2014, 42 : 135 - 135
  • [8] Aldehyde Dehydrogenase-2 catalyzed bioactivation of Pentaerythrityl Tetranitrate
    Griesberger, Martina
    Woelkart, Gerald
    Kollau, Alexander
    Wenzl, Verena
    Beretta, Matteo
    Gorren, Antonius C. F.
    Schmidt, Kurt
    Mayer, Bernd
    [J]. NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 2010, 22 : S17 - S17
  • [9] Characterization of the East Asian Variant of Aldehyde Dehydrogenase-2 BIOACTIVATION OF NITROGLYCERIN AND EFFECTS OF Alda-1
    Beretta, Matteo
    Gorren, Antonius C. F.
    Wenzl, M. Verena
    Weis, Robert
    Russwurm, Michael
    Koesling, Doris
    Schmidt, Kurt
    Mayer, Bernd
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (02) : 943 - 952
  • [10] Bioactivation of nitroglycerin by the mitochondrial aldehyde dehydrogenase
    Chen, Zhiqiang
    Stamler, Jonathan S.
    [J]. TRENDS IN CARDIOVASCULAR MEDICINE, 2006, 16 (08) : 259 - 265