Experimental infection of inbred BALB/c and A/J mice with Massachusetts and Brazilian strains of infectious bronchitis virus (IBV)

被引:0
|
作者
Matheus C. Martini
Jacy Gameiro
Tereza Cristina Cardoso
Leonardo C. Caserta
Ana Carolina M. Gualberto
Lara Borges Keid
Trícia M. F. de S. Oliveira
Marcia M. A. B. dos Santos
Clarice W. Arns
Helena L. Ferreira
机构
[1] FZEA-USP,Laboratory of Animal Virology, Institute of Biology
[2] University of Campinas-UNICAMP,undefined
[3] ICB-Universidade Federal de Juiz de Fora,undefined
[4] UNESP-Univ Estadual Paulista,undefined
[5] College of Veterinary Medicine,undefined
来源
Archives of Virology | 2015年 / 160卷
关键词
Virus; Mice; Avian; Pneumonia;
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学科分类号
摘要
The ability of avian coronaviruses to replicate in mice was investigated to investigate interspecies transmission. Two inbred mouse strains (BALB/c and A/J) with different genetic backgrounds were inoculated with the avian coronavirus strains Mass and BR-I and monitored for at least 10 days. Analysis of viral RNA, histopathological examinations, immunohistochemistry and serology were performed. After virus inoculation, neither clinical signs nor evident gross lesions were observed. Viral RNA, histopathological changes, and viral nucleoprotein were observed in the lung, trachea and sinus of all inoculated mice. Our study demonstrates the importance of elucidating the epidemiology of coronaviruses, including in rodents that are pests in poultry production.
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页码:1785 / 1790
页数:5
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