A role for collagen XXIII in cancer cell adhesion, anchorage-independence and metastasis

被引:0
|
作者
K A Spivey
I Chung
J Banyard
I Adini
H A Feldman
B R Zetter
机构
[1] Vascular Biology Program,Department of Surgery
[2] Karp Family Research Laboratories,undefined
[3] Children's Hospital,undefined
[4] Clinical Research Program,undefined
[5] Children's Hospital Boston,undefined
来源
Oncogene | 2012年 / 31卷
关键词
collagen; metastasis; adhesion; anchorage-independence;
D O I
暂无
中图分类号
学科分类号
摘要
Collagen XXIII is a transmembrane collagen previously shown to be upregulated in metastatic prostate cancer that has been used as a tissue and fluid biomarker for non-small cell lung cancer and prostate cancer. To determine whether collagen XXIII facilitates cancer cell metastasis in vivo and to establish a function for collagen XXIII in cancer progression, collagen XXIII knockdown cells were examined for alterations in in vivo metastasis as well as in vitro cell adhesion. In experimental and spontaneous xenograft models of metastasis, H460 cells expressing collagen XXIII shRNA formed fewer lung metastases than control cells. Loss of collagen XXIII in H460 cells also impaired cell adhesion, anchorage-independent growth and cell seeding to the lung, but did not affect cell proliferation. Corroborating a role for collagen XXIII in cell adhesion, overexpression of collagen XXIII in H1299 cells, which do not express endogenous collagen XXIII, enhanced cell adhesion. Consequent reduction in OB-cadherin, alpha-catenin, gamma-catenin, beta-catenin, vimentin and galectin-3 protein expression was also observed in response to loss of collagen XXIII. This study suggests a potential role for collagen XXIII in mediating metastasis by facilitating cell–cell and cell–matrix adhesion as well as anchorage-independent cell growth.
引用
收藏
页码:2362 / 2372
页数:10
相关论文
共 50 条
  • [21] Doxycycline-Regulated p16MTS1 Expression Suppresses the Anchorage-Independence and Tumorigenicity of Breast Cancer Cell Lines that Lack Endogenous p16
    Todd, Maria C.
    Langan, Thomas A.
    Sclafani, Robert A.
    JOURNAL OF CANCER, 2017, 8 (02): : 190 - 198
  • [22] Cancer cell adhesion, metastasis, and the immune response
    Mierke, Claudia Tanja
    FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2023, 11
  • [23] SIRT3/SOD2/H2O2-mediated redox signaling supports ovarian cancer anchorage-independence
    Tang, Priscilla
    Elhaw, Amal
    Benson, James
    Wallace, Callen
    St Croix, Claudette
    Happe, Cassandra
    Mullett, Steve
    Gelhaus, Stacy
    Trebak, Mohamed
    Cunniff, Brian
    Hempel, Nadine
    FREE RADICAL BIOLOGY AND MEDICINE, 2023, 208 : S110 - S111
  • [24] Inhibition of IGF-I receptor in anchorage-independence attenuates GSK-3β constitutive phosphorylation and compromises growth and survival of medulloblastoma cell lines
    K Urbanska
    J Trojanek
    L Del Valle
    M B Eldeen
    F Hofmann
    C Garcia-Echeverria
    K Khalili
    K Reiss
    Oncogene, 2007, 26 : 2308 - 2317
  • [25] Unraveling the role of integrating signal peptides into natural collagen on modulating cancer cell adhesion
    Hou, Yuanjing
    Li, Fang
    Liu, Wei
    Guo, Ruiming
    Wu, Hui
    Huang, Siying
    Xu, Chengzhi
    Zhu, Lian
    Zhang, Juntao
    Wei, Benmei
    Wang, Haibo
    INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2024, 283
  • [26] Inhibition of IGF-I receptor in anchorage-independence attenuates GSK-3β constitutive phosphorylation and compromises growth and survival of medulloblastoma cell lines
    Urbanska, K.
    Trojanek, J.
    Del Valle, L.
    Eldeen, M. B.
    Hofmann, F.
    Garcia-Echeverria, C.
    Khalili, K.
    Reiss, K.
    ONCOGENE, 2007, 26 (16) : 2308 - 2317
  • [27] Role of the interaction between galectin-3 and cell adhesion molecules in cancer metastasis
    Xin, Ming
    Dong, Xin-Wen
    Guo, Xiu-Li
    BIOMEDICINE & PHARMACOTHERAPY, 2015, 69 : 179 - 185
  • [28] INVERSE CORRELATION OF COLLAGEN PRODUCTION TO ANCHORAGE INDEPENDENCE AND TUMORIGENICITY IN W8-CELL AND M-CELL LINES
    SMITH, BD
    MAHONEY, AP
    FELDMAN, RS
    CANCER RESEARCH, 1983, 43 (09) : 4275 - 4282
  • [29] PIK3CB is involved in metastasis through the regulation of cell adhesion to collagen I in pancreatic cancer
    Qu, Jianhua
    Zheng, Biao
    Ohuchida, Kenoki
    Feng, Haimin
    Chong, Stephen Jun Fei
    Zhang, Xianbin
    Liang, Rui
    Liu, Zhong
    Shirahane, Kengo
    Mizumoto, Kazuhiro
    Gong, Peng
    Nakamura, Masafumi
    JOURNAL OF ADVANCED RESEARCH, 2021, 33 : 127 - 140
  • [30] THROMBOSPONDIN AS A MEDIATOR OF CANCER CELL-ADHESION IN METASTASIS
    WALZ, DA
    CANCER AND METASTASIS REVIEWS, 1992, 11 (3-4) : 313 - 324