The Leading Role of Membrane Ca2+-ATPase in Recovery of Ca2+ Homeostasis after Glutamate Shock

被引：0
|
作者：
T. P. Storozhevykh
V. G. Pinelis
N. P. Vinskaya
A. M. Surin
B. I. Khodorov
机构：
[1] Russian Academy of Medical Sciences,Laboratory of Membranology, Research Center of Children Health
[2] Institute of General Pathology and Pathological Physiology,Russian Academy of Medical Sciences
来源：
Bulletin of Experimental Biology and Medicine | 2003年 / 135卷
关键词：
neuron; glutamate; neurotoxicity; Ca; -ATPase; Na; /Ca; -exchange;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Combined blockade of Na+/Ca2+ exchange, Ca2+ uptake by mitochondria and endoplasmic reticulum usually does not prevent recovery of the basal level of intracellular Ca2+ after 1-min action of glutamate (100 μM) or K+ (50 mM). However, replacement of Ca2+ with Ba2+, which cannot be transported by Ca2+-ATPase, considerably delayed the decrease in intracellular Ba2+ after its rise caused by glutamate or potassium application in all examined cells, which attest to an important role of Ca2+-ATPase in Ca2+ extrusion after the action of glutamate or K+.
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页码：139 / 142
页数：3
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