Expression of Markers of Regulatory CD4+CD25+foxp3+ Cells in Atherosclerotic Plaques of Human Coronary Arteries

被引：0
|
作者：
V. O. Sokolov
T. L. Krasnikova
L. V. Prokofieva
N. B. Kukhtina
T. I. Arefieva
机构：
[1] Russian Medical Technologies,Russian Cardiology Research
来源：
Bulletin of Experimental Biology and Medicine | 2009年 / 147卷
关键词：
human regulatory T cells; atherosclerosis; chemokines; migration;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The content of marker foxp3 of regulatory T cells and chemokines in atherosclerotic plaques of human coronary arteries was measured by the polymerase chain reaction. In vitro migration of regulatory CD4+CD25+foxp3+ cells in the CD4+ lymphocyte population from healthy donors was studied after treatment with chemokines I-309, IP-10, and SDF-1. mRNA for the factor foxp3 and chemokines SDF-1, I-309, and MIP-1β were found in the majority of samples from atherosclerotic plaques. SDF-1 induced maximum migratory response of CD4+CD25+foxp3+ cells.
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页码：726 / 729
页数：3
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