Studying the rigidity of red blood cells induced by Plasmodium falciparum infection

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作者：
Apurba Paul
Ghania Ramdani
Utpal Tatu
Gordon Langsley
Vasant Natarajan
机构：
[1] Indian Institute of Science,Department of Physics
[2] Inserm U1016,Department of Biochemistry
[3] CNRS UMR8104,undefined
[4] Cochin Institute,undefined
[5] Indian Institute of Science,undefined
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Scientific Reports | / 9卷
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摘要：
We study the effect of different chemical moieties on the rigidity of red blood cells (RBCs) induced by Plasmodium falciparum infection, and the bystander effect previously found. The infected cells are obtained from a culture of parasite-infected RBCs grown in the laboratory. The rigidity of RBCs is measured by looking at the Brownian fluctuations of individual cells in an optical-tweezers trap. The results point towards increased intracellular cyclic adenosine monophosphate (cAMP) levels as being responsible for the increase in rigidity.
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