PD-1 inhibitors plus chemotherapy in EGFR/ALK-positive NSCLC patients with brain metastases and disease progression after EGFR/ALK-TKIs therapy

被引:0
|
作者
Yixiang Zhu
Ye Zhang
Xingsheng Hu
Mingzhao Wang
Hongyu Wang
Yutao Liu
机构
[1] National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Department of Medical Oncology
[2] Chinese Academy of Medical Sciences and Peking Union Medical College,Department of Radiation Oncology
[3] National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,undefined
[4] Chinese Academy of Medical Sciences and Peking Union Medical College,undefined
关键词
EGFR mutation or ALK rearrangement; Brain metastasis; Immune checkpoint inhibitor (ICI); Chemotherapy;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:3557 / 3566
页数:9
相关论文
共 50 条
  • [21] Brigatinib After Progression From Alectinib or Crizotinib: Paving the Way for Treatment Sequencing of ALK Inhibitors in ALK-Positive NSCLC
    Song, Lianxi
    Xu, Qinqin
    Lizaso, Analyn
    Zhang, Yongchang
    JOURNAL OF THORACIC ONCOLOGY, 2021, 16 (03) : 349 - 351
  • [22] Continuation of EGFR/ALK inhibition after local therapy of oligoprogressive disease in EGFR mutant (Mt) and ALK plus non-small cell lung cancer (NSCLC)
    Weickhardt, Andrew James
    Scheier, Benjamin
    Burke, Joseph Malachy
    Gan, Gregory
    Doebele, Robert Charles
    Bunn, Paul A.
    Gaspar, Laurie E.
    Kavanagh, Brian D.
    Camidge, D. Ross
    JOURNAL OF CLINICAL ONCOLOGY, 2012, 30 (15)
  • [23] Upregulation of PD-L1 by EML4-ALK fusion protein mediates the immune escape in ALK positive NSCLC: Implication for optional anti-PD-1/PD-L1 immune therapy for ALK-TKIs sensitive and resistant NSCLC patients
    Hong, Shaodong
    Chen, Nan
    Fang, Wenfeng
    Zhan, Jianhua
    Liu, Qing
    Kang, Shiyang
    He, Xiaobo
    Liu, Lin
    Zhou, Ting
    Huang, Jiaxing
    Chen, Ying
    Qin, Tao
    Zhang, Yaxiong
    Ma, Yuxiang
    Yang, Yunpeng
    Zhao, Yuanyuan
    Huang, Yan
    Zhang, Li
    ONCOIMMUNOLOGY, 2016, 5 (03):
  • [24] Rh-endostatin Combined With PD-1 inhibitors as Firstline Treatment for EGFR/ALK-Negative, Nonsquamous NSCLC
    Wang, D.
    Feng, Y.
    Wang, H.
    Peng, H.
    Zhang, W.
    Su, W.
    Li, H.
    Hu, B.
    Bai, Y.
    Ma, H.
    Huang, L.
    Zhu, T.
    Qian, H.
    Li, Y.
    Fang, X.
    Ren, B.
    JOURNAL OF THORACIC ONCOLOGY, 2023, 18 (11) : S618 - S618
  • [25] EGFR TKIs plus WBRT Demonstrated No Survival Benefit Other Than That of TKIs Alone in Patients with NSCLC and EGFR Mutation and Brain Metastases
    Jiang, Tao
    Su, Chunxia
    Li, Xuefei
    Zhao, Chao
    Zhou, Fei
    Ren, Shengxiang
    Zhou, Caicun
    Zhang, Jun
    JOURNAL OF THORACIC ONCOLOGY, 2016, 11 (10) : 1718 - 1728
  • [26] Brain Metastases in EGFR- and ALK-Positive NSCLC : Outcomes of Central Nervous System-Penetrant Tyrosine Kinase Inhibitors Alone Versus in Combination With Radiation
    Thomas, Nicholas J.
    Myall, Nathaniel J.
    Sun, Fangdi
    Patil, Tejas
    Mushtaq, Rao
    Yu, Chandler
    Sinha, Sumi
    Pollom, Erqi L.
    Nagpal, Seema
    Camidge, D. Ross
    Rusthoven, Chad G.
    Braunstein, Steve E.
    Wakelee, Heather A.
    McCoach, Caroline E.
    JOURNAL OF THORACIC ONCOLOGY, 2022, 17 (01) : 116 - 129
  • [27] Alectinib provides a new option for ALK-positive NSCLC patients after progression on crizotinib
    Abraham, Jame
    JOURNAL OF COMMUNITY AND SUPPORTIVE ONCOLOGY, 2016, 14 (06): : 241 - 243
  • [28] Clinical benefit of continuing ALK inhibition with crizotinib beyond initial disease progression in patients with advanced ALK-positive NSCLC
    Ou, S. -H. I.
    Jaenne, P. A.
    Bartlett, C. H.
    Tang, Y.
    Kim, D. -W.
    Otterson, G. A.
    Crino, L.
    Selaru, P.
    Cohen, D. P.
    Clark, J. W.
    Riely, G. J.
    ANNALS OF ONCOLOGY, 2014, 25 (02) : 415 - 422
  • [29] Clinical benefit of continuing ALK inhibition with crizotinib beyond initial disease progression in patients with advanced ALK-positive NSCLC
    Leduc, C.
    Besse, B.
    ANNALS OF ONCOLOGY, 2014, 25 (10) : 2092 - 2092
  • [30] EGFR-TKIs plus bevacizumab demonstrated survival benefit than EGFR-TKIs alone in EGFR-mutant NSCLC patients with multiple brain metastases
    Jiang, T.
    Zhou, C.
    ANNALS OF ONCOLOGY, 2019, 30