Targeted next-generation sequencing reveals high frequency of mutations in epigenetic regulators across treatment-naïve patient melanomas

被引：0
|
作者：
Jonathan J. Lee
Lynette M. Sholl
Neal I. Lindeman
Scott R. Granter
Alvaro C. Laga
Priyanka Shivdasani
Gary Chin
Jason J. Luke
Patrick A. Ott
F. Stephen Hodi
Martin C. Mihm
Jennifer Y. Lin
Andrew E. Werchniak
Harley A. Haynes
Nancy Bailey
Robert Liu
George F. Murphy
Christine G. Lian
机构：
[1] Brigham and Women’s Hospital,Department of Pathology
[2] Harvard Medical School,undefined
[3] Melanoma Center,undefined
[4] Dana–Farber Cancer Institute,undefined
[5] Harvard Medical School,undefined
来源：
Clinical Epigenetics | 2015年 / 7卷
关键词：
Melanoma; Next-generation sequencing (NGS); Epigenetics; (MDS1 and EV1 complex locus); Ten-eleven translocation (TET); Isocitrate dehydrogenase 2 (IDH2); 5-hydroxymethylcytosine; DNA demethylation;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 50 条
  • [1] Targeted next-generation sequencing reveals high frequency of mutations in epigenetic regulators across treatment-naive patient melanomas
    Lee, Jonathan J.
    Sholl, Lynette M.
    Lindeman, Neal I.
    Granter, Scott R.
    Laga, Alvaro C.
    Shivdasani, Priyanka
    Chin, Gary
    Luke, Jason J.
    Ott, Patrick A.
    Hodi, F. Stephen
    Mihm, Martin C., Jr.
    Lin, Jennifer Y.
    Werchniak, Andrew E.
    Haynes, Harley A.
    Bailey, Nancy
    Liu, Robert
    Murphy, George F.
    Lian, Christine G.
    CLINICAL EPIGENETICS, 2015, 7
  • [2] Targeted Next Generation Sequencing of Treatment-Naive Metastatic Melanoma Specimens Reveals High Frequency of Epigenetic Alterations
    Lee, Jonathan
    Lindeman, Neal
    Chin, Gary
    Luke, Jason
    Ott, Patrick
    Hodi, F. Stephen
    Granter, Scott
    Laga, Alvaro
    Yoon, Charles
    Haynes, Harley
    Werchniak, Andrew
    Lin, Jennifer
    Liu, Robert
    Bailey, Nancy
    Murphy, George
    Lian, Christine
    MODERN PATHOLOGY, 2015, 28 : 459A - 460A
  • [3] Targeted Next Generation Sequencing of Treatment-Naive Metastatic Melanoma Specimens Reveals High Frequency of Epigenetic Alterations
    Lee, Jonathan
    Lindeman, Neal
    Chin, Gary
    Luke, Jason
    Ott, Patrick
    Hodi, F. Stephen
    Granter, Scott
    Laga, Alvaro
    Yoon, Charles
    Haynes, Harley
    Werchniak, Andrew
    Lin, Jennifer
    Liu, Robert
    Bailey, Nancy
    Murphy, George
    Lian, Christine
    LABORATORY INVESTIGATION, 2015, 95 : 459A - 460A
  • [4] A High Frequency of Mutations Is Detected in Endometrial Cancer Using a Targeted Next-Generation Sequencing Approach
    Voss, J. S.
    Kipp, B. R.
    Winterhoff, B. J.
    Vasmatzis, G.
    Wang, C.
    Mariani, A.
    Kerr, S. E.
    JOURNAL OF MOLECULAR DIAGNOSTICS, 2013, 15 (06): : 925 - 925
  • [5] Targeted next-generation sequencing detects a high frequency of potentially actionable mutations in metastatic breast cancers
    Muller, Kristen E.
    Marotti, Jonathan D.
    de Abreu, Francine B.
    Peterson, Jason D.
    Miller, Todd W.
    Chamberlin, Mary D.
    Tsongalis, Gregory J.
    Tafe, Laura J.
    EXPERIMENTAL AND MOLECULAR PATHOLOGY, 2016, 100 (03) : 421 - 425
  • [6] Next-Generation Sequencing of Pulmonary Sarcomatoid Carcinoma Reveals High Frequency of Actionable MET Gene Mutations
    Liu, Xuewen
    Jia, Yuxia
    Stoopler, Mark B.
    Shen, Yufeng
    Cheng, Haiying
    Chen, Jinli
    Mansukhani, Mahesh
    Koul, Sanjay
    Halmos, Balazs
    Borczuk, Alain C.
    JOURNAL OF CLINICAL ONCOLOGY, 2016, 34 (08) : 794 - +
  • [7] Targeted Next-Generation Sequencing Reveals Novel TTN Mutations Causing Recessive Distal Titinopathy
    Evila, Anni
    Palmio, Johanna
    Vihola, Anna
    Savarese, Marco
    Tasca, Giorgio
    Penttila, Sini
    Lehtinen, Sara
    Jonson, Per Harald
    De Bleecker, Jan
    Rainer, Peter
    Auer-Grumbach, Michaela
    Pouget, Jean
    Salort-Campana, Emmanuelle
    Vilchez, Juan J.
    Muelas, Nuria
    Olive, Montse
    Hackman, Peter
    Udd, Bjarne
    MOLECULAR NEUROBIOLOGY, 2017, 54 (09) : 7212 - 7223
  • [8] Targeted next-generation sequencing of candidate genes reveals novel mutations in patients with dilated cardiomyopathy
    Zhao, Yue
    Feng, Yue
    Zhang, Yun-Mei
    Ding, Xiao-Xue
    Song, Yu-Zhu
    Zhang, A-Mei
    Liu, Li
    Zhang, Hong
    Ding, Jia-Huan
    Xia, Xue-Shan
    INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2015, 36 (06) : 1479 - 1486
  • [9] Targeted Next-Generation Sequencing Reveals Cancer-Related Mutations in Duodenal Hyperplastic Polyps
    Salomao, Marcela
    Luna, Aesis
    Sepulveda, Jorge
    Sepulveda, Antonia
    LABORATORY INVESTIGATION, 2015, 95 : 190A - 190A
  • [10] Targeted next-generation sequencing reveals novel TTN mutations causing recessive distal titinopathy
    Evila, A.
    Penttila, S.
    Hackman, P.
    Udd, B.
    NEUROMUSCULAR DISORDERS, 2015, 25 : S282 - S283
12345