Activin-A impedes the establishment of CD4+ T cell exhaustion and enhances anti-tumor immunity in the lung

被引：0
|
作者：
Ioannis Morianos
Aikaterini Tsitsopoulou
Konstantinos Potaris
Dimitrios Valakos
Ourania Fari
Giannis Vatsellas
Clementine Bostantzoglou
Andreas Photiades
Mina Gaga
Georgina Xanthou
Maria Semitekolou
机构：
[1] Cellular Immunology Laboratory,Department of Thoracic Surgery
[2] Biomedical Research Foundation of the Academy of Athens (BRFAA),Present address: Department of Medicine I, Comprehensive Cancer Center, Institute of Cancer Research
[3] Athens Chest Hospital ‘Sotiria’,Intensive Care Unit
[4] Molecular Biology Laboratory,7th Respiratory Medicine Department and Asthma Center
[5] BRFAA,undefined
[6] Medical University of Vienna,undefined
[7] Greek Genome Center,undefined
[8] BRFAA,undefined
[9] Athens Chest Hospital ‘Sotiria’,undefined
[10] Athens Chest Hospital ‘Sotiria’,undefined
来源：
Journal of Experimental & Clinical Cancer Research | / 40卷
关键词：
Activin-A; Anti-tumor immunity; CD4; T cells; Non-small cell lung cancer; T cell exhaustion; Immune regulation;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 50 条
  • [21] Coenzyme A fuels T cell anti-tumor immunity
    St Paul, Michael
    Saibil, Samuel D.
    Han, SeongJun
    Israni-Winger, Kavita
    Lien, Scott C.
    Laister, Rob C.
    Sayad, Azin
    Penny, Susanne
    Amaria, Rodabe N.
    Haydu, Lauren E.
    Garcia-Batres, Carlos R.
    Kates, Meghan
    Mulder, David T.
    Robert-Tissot, Celine
    Gold, Matthew J.
    Tran, Charles W.
    Elford, Alisha R.
    Nguyen, Linh T.
    Pugh, Trevor J.
    Pinto, Devanand M.
    Wargo, Jennifer A.
    Ohashi, Pamela S.
    CELL METABOLISM, 2021, 33 (12) : 2415 - +
  • [22] Remodeling translation primes CD8+T cell anti-tumor immunity
    Thaxton, Jessica
    Lawrence, Kiley
    Hurst, Katie
    Ball, Lauren
    Leddy, Lee
    Chung, Dongjun
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2019, 7
  • [23] Bryostatin exerts anti-tumor effects by reversing T cell exhaustion
    Zhao, Manzhi
    Li, Ling
    Kiernan, Caoimhe H.
    Ruijten, Rik
    Alofs, Tessa
    Van Meurs, Marjan
    Haspels, Inge Brouwers
    Mueller, Yvonne M.
    Katsikis, Peter D.
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2021, 51 : 45 - 45
  • [24] Sirt2 inhibition enhances anti-tumor immunity by promoting T cell metabolism
    Hamaidi, Imene
    Zhang, Lin
    Kim, Nayoung
    Wang, Min-Hsuan
    Iclozan, Cristina
    Fang, Bin
    Liu, Min
    Koomen, John
    Berglund, Anders
    Yoder, Sean
    Yao, Jiqiang
    Creelan, Ben
    Antonia, Scott
    Kim, Sungjune
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2019, 7
  • [25] Tumor-specific CD4+ T cells have a major "post-licensing" role in CTL mediated anti-tumor immunity
    Marzo, AL
    Kinnear, BF
    Lake, RA
    Frelinger, JJ
    Collins, EJ
    Robinson, BWS
    Scott, B
    JOURNAL OF IMMUNOLOGY, 2000, 165 (11): : 6047 - 6055
  • [26] Frizzled-4 expression enhances hepatocellular carcinoma progression, sorafenib resistance and suppresses anti-tumor CD8 T cell immunity
    Luo, Jie
    Gong, Lanqi
    Yang, Yuma
    Liu, Qin
    Huang, Jiao
    Fang, Xiaona
    Guan, Xin-Yuan
    CANCER RESEARCH, 2023, 83 (07)
  • [27] Methylmalonic acid induces metabolic abnormalities and exhaustion in CD8+ T cells to suppress anti-tumor immunity
    Tejero, Joanne D.
    Hesterberg, Rebecca S.
    Drapela, Stanislav
    Ilter, Didem
    Raizada, Devesh
    Lazure, Felicia
    Kashfi, Hossein
    Liu, Min
    Silvane, Leonardo
    Avram, Dorina
    Fernandez-Garcia, Juan
    Asara, John M.
    Fendt, Sarah-Maria
    Cleveland, John L.
    Gomes, Ana P.
    ONCOGENE, 2025, 44 (02) : 105 - 114
  • [28] Selective regulatory T cell depletion by anti-CCR8 antibody enhances anti-tumor immunity
    Ohkura, Naganari
    Yasumizu, Yoshiaki
    Hagiwara, Masaki
    Kidani, Yujiro
    Fuji, Hiroaki
    Iwaisako, Keiko
    Nakamura, Yamami
    Sakaguchi, Shimon
    CANCER SCIENCE, 2025, 116 : 806 - 806
  • [29] Anti-CD47 treatment enhances anti-tumor T-cell immunity and improves immunosuppressive environment in head and neck squamous cell carcinoma
    Wu, Lei
    Yu, Guang-Tao
    Deng, Wei-Wei
    Mao, Liang
    Yang, Lei-Lei
    Ma, Si-Rui
    Bu, Lin-Lin
    Kulkarni, Ashok B.
    Zhang, Wen-Feng
    Zhang, Lu
    Sun, Zhi-Jun
    ONCOIMMUNOLOGY, 2018, 7 (04):
  • [30] Intratumoral CD4+ T Cells Mediate Anti-tumor Cytotoxicity in Human Bladder Cancer
    Oh, David Y.
    Kwek, Serena S.
    Raju, Siddharth S.
    Li, Tony
    McCarthy, Elizabeth
    Chow, Eric
    Aran, Dvir
    Ilano, Arielle
    Pai, Chien-Chun Steven
    Rancan, Chiara
    Allaire, Kathryn
    Burra, Arun
    Sun, Yang
    Spitzer, Matthew H.
    Mangul, Serghei
    Porten, Sima
    Meng, Maxwell, V
    Friedlander, Terence W.
    Ye, Chun Jimmie
    Fong, Lawrence
    CELL, 2020, 181 (07) : 1612 - +
12345