Interleukin-6 levels in synovial fluids of patients with rheumatoid arthritis correlated with the infiltration of inflammatory cells in synovial membrane

被引：0
|
作者：
Tomoko Matsumoto
Toshiyuki Tsurumoto
Hiroyuki Shindo
机构：
[1] Nagasaki University,Department of Orthopedic Surgery, School of Medicine
来源：
Rheumatology International | 2006年 / 26卷
关键词：
Rheumatoid arthritis; Synovial membrane; Synovial fluid; Interleukin-6;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
To compare the histological appearance of synovial membrane and interleukin (IL)-6 levels in synovial fluids of patients with rheumatoid arthritis (RA). Synovial tissue and synovial fluids were obtained from 51 knee joints with RA undergoing synovectomy or joint replacements. A histological inflammation score was determined based on the hyperplasia of the synovial lining and infiltration of inflammatory cells. The concentrations of IL-6 in synovial fluids were measured by ELISA. The association between IL-6 levels and histological findings was evaluated. We found a positive correlation between the infiltration of inflammation cells in synovial tissues and the concentration of IL-6 in synovial fluids. The IL-6 level in synovial fluid partially reflects histological synovial inflammation.
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页码：1096 / 1100
页数：4
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