The Role of Metabolites of Antidepressants in the Treatment of Depression

被引：0
|
作者：
Matthew V. Rudorfer
William Z. Potter
机构：
[1] National Institute of Mental Health,Clinical Treatment Research Branch, Division of Clinical and Treatment Research
[2] National Institute of Mental Health,Section on Clinical Pharmacology, Experimental Therapeutics Branch
[3] Eli Lilly & Co.,undefined
来源：
CNS Drugs | 1997年 / 7卷
关键词：
Adis International Limited; Fluoxetine; Venlafaxine; Desipramine; Clomipramine;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Recognition of the role of active metabolites in mediating therapeutic and/or adverse effects of many antidepressants is an important part of understanding the mechanisms of action of these medications. While virtually all antidepressants except lithium undergo extensive hepatic metabolism, the profile of activity of the resulting breakdown products varies considerably.
引用
收藏
页码：273 / 312
页数：39
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