After first describing the issue contents (Biophysical Reviews—Volume 12 Issue 6), this Editorial goes on to provide a short round-up of the activities of the journal in 2020. Directly following this Editorial are two obituaries marking the recent deaths of Prof. Fumio Oosawa (Japan) and Dr. Herbert Tabor (USA)—two major figures in Biophysical/Biochemical science from the last 100 years.