Azithromycin Reduces the Production of α-hemolysin and Biofilm Formation in Staphylococcus aureus

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作者
Zhihong Gui
Huafu Wang
Ting Ding
Wei Zhu
Xiyi Zhuang
Weihua Chu
机构
[1] Lishui People’s Hospital,Department of Microbiology, School of Life Science and Technology
[2] China Pharmaceutical University,undefined
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关键词
Azithromycin; Biofilm; α-hemolysin;
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摘要
Staphylococcus aureus causes a broad range of life-threatening diseases in humans. This bacterium produces a large number of extracellular virulence factors that are closely associated with specific diseases which are controlled by quorum sensing. In this study, we show that azithromycin was active against methicillin-resistant Staphylococcus aureus (MRSA) strains with MICs ranged from 32 to 64 μg/mL. Azithromycin at subinhibitory concentration, markedly reduced the production of α-hemolysin at (1/16MIC, 1/8MIC) and biofilm formation at (1/16MIC, 1/8MIC), respectively. The results indicated that sub-inhibitory concentrations of azithromycin decreased the production of α-hemolysin and biofilm formation in MRSA in a dose-dependent manner. Therefore, azithromycin may be useful in the treatment of α-hemolysin producing and biofilm formation MRSA infections.
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页码:114 / 117
页数:3
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