Phase IB study of sorafenib in combination with gemcitabine and cisplatin in patients with refractory solid tumors

被引:0
|
作者
B. Schultheis
G. Kummer
M. Zeth
E. Brendel
C. Xia
M. Kornacker
D. Strumberg
机构
[1] University of Bochum (Marienhospital Herne),Department of Haematology and Medical Oncology
[2] Bayer HealthCare Pharmaceuticals,undefined
[3] Bayer HealthCare Pharmaceuticals,undefined
[4] Bayer HealthCare Pharmaceuticals,undefined
来源
关键词
Phase I; Sorafenib; Gemcitabine; Cisplatin; Multiple kinase inhibitor; Pharmacokinetics;
D O I
暂无
中图分类号
学科分类号
摘要
引用
下载
收藏
页码:333 / 339
页数:6
相关论文
共 50 条
  • [11] Phase I pharmacokinetic and pharmacodynamic study of lapatinib in combination with sorafenib in patients with advanced refractory solid tumors
    Simonelli, Matteo
    Zucali, Paolo A.
    Lorenzi, Elena
    Rubino, Luca
    De Vincenzo, Fabio
    De Sanctis, Rita
    Perrino, Matteo
    Mancini, Luca
    Di Tommaso, Luca
    Rimassa, Lorenza
    Masci, Giovanna
    Zuradelli, Monica
    Suter, Matteo B.
    Bertossi, Monica
    Fattuzzo, Giuseppe
    Giordano, Laura
    Roncalli, Massimo G.
    Santoro, Armando
    EUROPEAN JOURNAL OF CANCER, 2013, 49 (05) : 989 - 998
  • [12] A phase Ib study of AZD1775 and olaparib combination in patients with refractory solid tumors.
    Hamilton, Erika Paige
    Wang, Judy Sing-Zan
    Falchook, Gerald
    Jones, Suzanne Fields
    Cook, Carl
    Mugundu, Ganesh
    Jewsbury, Philip John
    O'Connor, Mark J.
    Pierce, Andrewi
    Li, Bob T.
    Oza, Amit M.
    Infante, Jeffrey R.
    Burris, Howard A.
    Spigel, David R.
    JOURNAL OF CLINICAL ONCOLOGY, 2016, 34 (15)
  • [13] Phase I dose-escalation study of milciclib in combination with gemcitabine in patients with refractory solid tumors
    Sandrine Aspeslagh
    Kunwar Shailubhai
    Rastilav Bahleda
    Anas Gazzah
    Andréa Varga
    Antoine Hollebecque
    Christophe Massard
    Anna Spreafico
    Michele Reni
    Jean-Charles Soria
    Cancer Chemotherapy and Pharmacology, 2017, 79 : 1257 - 1265
  • [14] Phase I dose-escalation study of milciclib in combination with gemcitabine in patients with refractory solid tumors
    Aspeslagh, Sandrine
    Shailubhai, Kunwar
    Bahleda, Rastilav
    Gazzah, Anas
    Varga, Andrea
    Hollebecque, Antoine
    Massard, Christophe
    Spreafico, Anna
    Reni, Michele
    Soria, Jean-Charles
    CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2017, 79 (06) : 1257 - 1265
  • [15] Phase I study of 17-allylamino-17 demethoxygeldanamycin, gemcitabine and/or cisplatin in patients with refractory solid tumors
    Joleen Hubbard
    Charles Erlichman
    David O. Toft
    Rui Qin
    Bridget A. Stensgard
    Sara Felten
    Cynthia Ten Eyck
    Gretchen Batzel
    S. Percy Ivy
    Paul Haluska
    Investigational New Drugs, 2011, 29 : 473 - 480
  • [16] Phase I study of 17-allylamino-17 demethoxygeldanamycin, gemcitabine and/or cisplatin in patients with refractory solid tumors
    Hubbard, Joleen
    Erlichman, Charles
    Toft, David O.
    Qin, Rui
    Stensgard, Bridget A.
    Felten, Sara
    Ten Eyck, Cynthia
    Batzel, Gretchen
    Ivy, S. Percy
    Haluska, Paul
    INVESTIGATIONAL NEW DRUGS, 2011, 29 (03) : 473 - 480
  • [17] Phase Ib of Sorafenib in Combination With Everolimus in Patients With Advanced Solid Tumors, Selected on the Basis of Molecular Targets
    Toffalorio, Francesca
    Spitaleri, Gianluca
    Catania, Chiara
    Dal Zotto, Laura
    Noberasco, Cristina
    Delmonte, Angelo
    Santarpia, Mariacarmela
    Vecchio, Fabio
    Brunelli, Veronica
    Rampinelli, Cristiano
    Barberis, Amassimo
    Fumagalli, Caterina
    Zucchetti, Massimo
    Zangarini, Monique
    Diena, Tullia
    Danesi, Romano
    De Braud, Filippo
    De Pas, Tommaso
    ONCOLOGIST, 2014, 19 (04): : 344 - 345
  • [18] THE COMBINATION OF SORAFENIB AND EVEROLIMUS IN PATIENTS WITH SOLID TUMORS - RESULTS OF A PHASE I STUDY
    Nogova, Lucia
    Mattonet, Christian
    Scheffler, Matthias
    Papachristou, Irini
    Muthen, Noemi
    Sos, Martin
    Topelt, Karin
    Hacker, Ulrich
    Elter, Thomas
    Backes, Heiko
    Kobe, Carsten
    Rhiem, Kerstin
    Mallmann, Peter
    Fuhr, Uwe
    Schnell, Roland
    Katay, Ildiko
    Reiser, Marcel
    Harbeck, Nadia
    Dietlein, Markus
    Wolf, Jurgen
    JOURNAL OF THORACIC ONCOLOGY, 2011, 6 (06) : S1568 - S1568
  • [19] A Phase I study of sorafenib in combination with capecitabine in patients with advanced, solid tumors
    Awada, A.
    Gil, T.
    Burk, K.
    Vanhamme, J.
    Mancini, I.
    Besse, T.
    Brendel, E.
    Matthys, A.
    Piccart, M.
    Hendlisz, A.
    EJC SUPPLEMENTS, 2006, 4 (12): : 33 - 34
  • [20] A phase I trial of gemcitabine plus paclitaxel combination therapy in patients with refractory solid tumors
    Sandler, A
    Raghavan, D
    Meropol, N
    Meyers, T
    Kindler, H
    Fox, S
    Perez, R
    Einhorn, LH
    EUROPEAN JOURNAL OF CANCER, 1997, 33 : 1120 - 1120