FANCD2 limits replication stress and genome instability in cells lacking BRCA2

被引：0
|
作者：
Johanna Michl
Jutta Zimmer
Francesca M Buffa
Ultan McDermott
Madalena Tarsounas
机构：
[1] CR-UK/MRC Oxford Institute for Radiation Oncology,Department of Oncology
[2] University of Oxford,undefined
[3] Cancer Genome Project,undefined
[4] Wellcome Trust Sanger Institute,undefined
来源：
Nature Structural & Molecular Biology | 2016年 / 23卷
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学科分类号：
摘要：
Probing the synthetic lethal effect of FANCD2 deletion in BRCA2-deficient cells reveals independent roles of FANCD2 and BRCA2 in stabilizing stalled replication forks to maintain genome stability and promote cell survival.
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页码：755 / 757
页数：2
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