FANCD2 limits replication stress and genome instability in cells lacking BRCA2

被引：0
|
作者：
Johanna Michl
Jutta Zimmer
Francesca M Buffa
Ultan McDermott
Madalena Tarsounas
机构：
[1] CR-UK/MRC Oxford Institute for Radiation Oncology,Department of Oncology
[2] University of Oxford,undefined
[3] Cancer Genome Project,undefined
[4] Wellcome Trust Sanger Institute,undefined
来源：
Nature Structural & Molecular Biology | 2016年 / 23卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Probing the synthetic lethal effect of FANCD2 deletion in BRCA2-deficient cells reveals independent roles of FANCD2 and BRCA2 in stabilizing stalled replication forks to maintain genome stability and promote cell survival.
引用
收藏
页码：755 / 757
页数：2
相关论文
共 50 条
  • [1] FANCD2 limits replication stress and genome instability in cells lacking BRCA2
    Michl, Johanna
    Zimmer, Jutta
    Buffa, Francesca M.
    McDermott, Ultan
    Tarsounas, Madalena
    NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2016, 23 (08) : 755 - +
  • [2] Functional interaction of monoubiquitinated FANCD2 and BRCA2/FANCD1 in chromatin
    Wang, XZ
    Andreassen, PR
    D'Andrea, AD
    MOLECULAR AND CELLULAR BIOLOGY, 2004, 24 (13) : 5850 - 5862
  • [3] Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways
    Hussain, S
    Wilson, JB
    Medhurst, AL
    Hejna, J
    Witt, E
    Ananth, S
    Davies, A
    Masson, JY
    Moses, R
    West, SC
    de Winter, JP
    Ashworth, A
    Jones, NJ
    Mathew, CG
    HUMAN MOLECULAR GENETICS, 2004, 13 (12) : 1241 - 1248
  • [4] FANCD2, FANCJ and BRCA2 cooperate to promote replication fork recovery independently of the Fanconi Anemia core complex
    Raghunandan, Maya
    Chaudhury, Indrajit
    Kelich, Stephanie L.
    Hanenberg, Helmut
    Sobeck, Alexandra
    CELL CYCLE, 2015, 14 (03) : 342 - 353
  • [5] FANCD2 limits acetaldehyde-induced genomic instability during DNA replication in esophageal keratinocytes
    Peake, Jasmine D.
    Noguchi, Chiaki
    Lin, Baicheng
    Theriault, Amber
    O'Connor, Margaret
    Sheth, Shivani
    Tanaka, Koji
    Nakagawa, Hiroshi
    Noguchi, Eishi
    MOLECULAR ONCOLOGY, 2021, 15 (11) : 3109 - 3124
  • [6] Ubiquitinated Fancd2 recruits Fan1 to stalled replication forks to prevent genome instability
    Lachaud, Christophe
    Moreno, Alberto
    Marchesi, Francesco
    Toth, Rachel
    Blow, J. Julian
    Rouse, John
    SCIENCE, 2016, 351 (6275) : 846 - 849
  • [7] Protein-Protein Interactions of Fanconi anemia proteins-FANCI, FANCD2 and BRCA2
    Siddiqui, Mohd Quadir
    Rajpurohit, Yogendra S.
    Misra, Hari S.
    Varma, Ashok K.
    ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, 2017, 73 : C455 - C455
  • [8] Clinical importance of FANCD2, BRIP1, BRCA1, BRCA2 and FANCF expression in ovarian carcinomas
    Moes-Sosnowska, Joanna
    Rzepecka, Iwona K.
    Chodzynska, Joanna
    Dansonka-Mieszkowska, Agnieszka
    Szafron, Lukasz M.
    Balabas, Aneta
    Lotocka, Renata
    Sobiczewski, Piotr
    Kupryjanczyk, Jolanta
    CANCER BIOLOGY & THERAPY, 2019, 20 (06) : 843 - 854
  • [9] BRCA1-independent ubiquitination of FANCD2
    Vandenberg, CJ
    Gergely, F
    Ong, CY
    Pace, P
    Mallery, DL
    Hiom, K
    Patel, KJ
    MOLECULAR CELL, 2003, 12 (01) : 247 - 254
  • [10] FANCD2 influences replication fork processes and genome stability in response to clustered DSBs
    Zhu, Jiayun
    Su, Fengtao
    Mukherjee, Shibani
    Mori, Eiichiro
    Hu, Burong
    Asaithamby, Aroumougame
    CELL CYCLE, 2015, 14 (12) : 1809 - 1822
12345