Resistance of CD28-deficient mice to autologous phase of anti-glomerular basement membrane glomerulonephritis

被引：8
|
作者：
Kosaku Nitta
Shigeru Horita
Shuhei Ogawa
Masayo Matsumoto
Yasushi Hara
Kazuhiro Okano
Tomohito Hayashi
Ryo Abe
Hiroshi Nihei
机构：
[1] Tokyo Women's Medical University,Department of Medicine, Kidney Center
[2] Science University of Tokyo,Research Institute for Biological Sciences
来源：
Journal of Clinical and Experimental Nephrology | 2003年 / 7卷 / 2期
关键词：
Mice; Kidney; CD28; Crescent; Glomerulonephritis;
D O I：
10.1007/s10157-003-0225-3
中图分类号：
学科分类号：
摘要：
Background. The engagement of CD28 on T cells provides an essential costimulatory signal for T-cell activation and differentiation. Recent studies suggest that CTLA4Ig inhibits T-cell activation in vitro and in vivo, prevents acute and chronic allograft rejection, and induces tolerance in some experimental transplantation models.
引用
收藏
页码：104 / 112
页数：8
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