Unexpected result in the reaction of 3-amino-3-thioxopropanamides with 2-anilinomethylene derivatives of 1,3-dicarbonyl compounds. synthesis of pyrimidine-5-carboxamide derivatives

被引：0

作者：

V. V. Dotsenko

K. A. Frolov

S. G. Krivokolysko

V. V. Polovinko

机构：

[1] Vladimir Dal’ East Ukrainian National University,“ChemEx” Laboratory

[2] Enamine Ltd,undefined

来源：

Chemistry of Heterocyclic Compounds | 2013年 / 49卷

关键词：

3-amino-3-thioxopropanamides; pyrimidine-5-carboxamides; thiomalonamides; alkylation; heterocyclization;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The interaction of 3-amino-3-thioxopropanamides with 2-anilinomethylene derivatives of dimedone, 1,3-cyclohexanedione and Meldrum’s acid led to the formation of 2-(2-amino-2-oxoethyl)-6-thioxo-1,6-dihydropyrimidine-5-carboxamides. The latter were alkylated in alkaline medium with the formation of 4-(alkylthio)pyrimidine-5-carboxamide derivatives.

引用

页码：440 / 451

页数：11

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