Unexpected result in the reaction of 3-amino-3-thioxopropanamides with 2-anilinomethylene derivatives of 1,3-dicarbonyl compounds. synthesis of pyrimidine-5-carboxamide derivatives

被引：0
|
作者：
V. V. Dotsenko
K. A. Frolov
S. G. Krivokolysko
V. V. Polovinko
机构：
[1] Vladimir Dal’ East Ukrainian National University,“ChemEx” Laboratory
[2] Enamine Ltd,undefined
来源：
Chemistry of Heterocyclic Compounds | 2013年 / 49卷
关键词：
3-amino-3-thioxopropanamides; pyrimidine-5-carboxamides; thiomalonamides; alkylation; heterocyclization;
D O I：
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学科分类号：
摘要：
The interaction of 3-amino-3-thioxopropanamides with 2-anilinomethylene derivatives of dimedone, 1,3-cyclohexanedione and Meldrum’s acid led to the formation of 2-(2-amino-2-oxoethyl)-6-thioxo-1,6-dihydropyrimidine-5-carboxamides. The latter were alkylated in alkaline medium with the formation of 4-(alkylthio)pyrimidine-5-carboxamide derivatives.
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页码：440 / 451
页数：11
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